Introduction: In patients with multiple sclerosis and patients after stroke, the hand function is often impaired, which affects their daily activities. In both patient groups The Nine Hole Peg Test is often used to assess fine motor skills of the hand. It measures the amount of time needed to insert nine pegs one by one with one hand into a board and then remove them as quickly as possible. Purpose: The purpose of the thesis was to conduct a literature review on the measurement properties of Nine Hole Peg Test in patients with multiple sclerosis and patients after stroke. Methods: The literature review was conducted in the PubMed database. The included studies had to meet the inclusion criteria. The review was constructed at the end of January 2019. Results: Eleven studies were included in the review. Reliability was assessed in five, validity in seven, and ability to detect changes in four studies. They were published between 2002 and 2017. The results show high to excellent intra-rater reliability in patients with multiple sclerosis and patients after stroke (ICC = 0.85–0.99) and moderate intra-rater reliability in patients with spasticity (ICC = 0.64). The inter-rater reliability in patients with multiple sclerosis was excellent (ICC = 0.98). The concurrent validity of The Nine Hole Peg Test was greater in assessing activity than function. The sensitivity of the test was decreased in patients with spasticity. Conclusion: The literature review showed that The Nine Hole Peg Test is a valid and reliable method to assess fine motor skills of patients with multiple sclerosis and after stroke. Further research on inter-rater reliability is needed in both groups of patients. The literature review provides a basis for further research on the effects of spasticity, ataxia, tremor, and cognitive impairment on its measurement properties. The known values of the minimal detectable change can serve as the basis for the study of minimal clinical important difference in both patient populations.
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