Introduction: Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant peripheral neuropathy. HNPP patients exhibit variously located recurrent peripheral nerve palsies in connection with sensory loss, often precipitated by a minor trauma or compression. Studies on nerve conduction reveal prolonged distal motor latencies, mildly decreased motor nerve conduction velocities predominantly at nerve entrapment sites, and altered sensory nerve action potentials. Aim: The purpose of our research was to identify changes in the studies of nerve conduction of patients with HNPP after a longer period of time (at least 10 years). We expected a deterioration of results due to the summation of compressions. Methods: Our study featured 15 patients with HNPP. We performed nerve conduction studies of the median, ulnar, fibular, and tibial motor nerves, as well as of the median, ulnar, radial, sural, and superficial peroneal sensory nerves. The data included in the final motor nerve conduction analysis were distal latency, amplitude, conduction velocity, and F wave latency of all four nerves. The data included in the final sensory nerve conduction analysis were latency, amplitude, and conduction velocity of the median, ulnar, and sural nerves. We statistically analysed the results with the Dependent T-test, using the Paired Sampled T-test in SPSS Statistics. Ethical approval was obtained for the study. Results: Having statistically analysed the data of the two motor nerve conduction studies, we found statistically significant prolonged distal motor latencies and F-wave latencies. After a statistical analysis of the data of the two sensory nerve conduction studies, we found statistically significant prolonged latencies and a statistically significant decline in the amplitude. Discussion and conclusion: Having compared the results of the two nerve conduction studies at least a decade apart, we can conclude that there is a deterioration of results. Changes are mostly seen in values most affected by mielin. For a more accrued comparison of the results, another nerve conduction study without an acutely worsened medical state of the patients is required. This would also enable us to compare the results of certain other nerves for which the data from the first study was insufficient for us to use.