In this work, we were interested in whether the fluorescently-labeled egerolysin proteins, ostreolysin A and erylsin A, bind to culture of differentiated nerve cells and to the human oral mucosal cells. We showed that fluorescently-labelled ostreolysin A binds to human nerve cells, since these cells contin lipid domains rich in cholesterol and sphingomyelin. On the other hand, erylysin A did not bind to this cell line. Simillary, fluorescently-tagged ostreolysin A binds to human oral mucosal cells, but the binding of fluorescently-tagged erilysin A was not observed.
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