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Social isolation during puberty affects female sexual behavior in mice
Kerčmar, Jasmina (Avtor), Tobet, Stuart (Avtor), Majdič, Gregor (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00337/abstract Povezava se odpre v novem oknu

Izvleček
Exposure to stress during puberty can lead to long-term behavioral alterations in adult rodents coincident with sex steroid hormone-dependent brain remodeling and reorganization. Social isolation is a stress for social animals like mice, but little is known about the effects of such stress during adolescence on later reproductive behaviors. The present study examined sexual behavior of ovariectomized, estradiol and progesterone primed female mice that were individually housed from 25 days of age until testing at approximately 95 days, or individually housed from day 25 until day 60 (during puberty), followed by housing in social groups. Mice in these isolated groups were compared to females that were group housed throughout the experiment. Receptive sexual behaviors of females and behaviors of stimulus males were recorded. Females housed in social groups displayed greater levels of receptive behaviors in comparison to both socially isolated groups. Namely, social females had higher lordosis quotients (LQs) and more often displayed stronger lordosis postures in comparison to isolated females. No differences between female groups were observed in stimulus male sexual behavior suggesting that female “attractiveness” was not affected by their social isolation. Females housed in social groups had fewer cells containing immunoreactive estrogen receptor (ER) α in the anteroventral periventricular nucleus (AVPV) and in the ventromedial nucleus of the hypothalamus (VMH) than both isolated groups. These results suggest that isolation during adolescence affects female sexual behavior and re-socialization for 1 month in adulthood is insufficient to rescue lordosis behavior from the effects of social isolation during the pubertal period.

Jezik:Angleški jezik
Ključne besede:mice, social isolation, female sexual behavior, estrogen receptor α, puberty, adolescence, molecular biology, behavior, animal, mice, female
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2014
Št. strani:str. 1-8
Številčenje:Vol. 8, No. e337
UDK:575
ISSN pri članku:1662-5153
DOI:10.3389/fnbeh.2014.00337 Povezava se odpre v novem oknu
COBISS.SI-ID:3874170 Povezava se odpre v novem oknu
Licenca:CC BY 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:121
Število prenosov:41
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Gradivo je del revije

Naslov:Frontiers in behavioral neuroscience
Skrajšan naslov:Front. behav. neurosci.
Založnik:Frontiers Research Foundation
ISSN:1662-5153
COBISS.SI-ID:20809480 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

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