MicroRNA polymorphisms in cancer : a literature analysis

Pipan, Veronika (avtor), Zorc, Minja (avtor), Kunej, Tanja (avtor)

Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes (miR-SNPs) have attracted increasing attention in recent years due to their involvement in the development of various types of cancer. Therefore, a systematic review on this topic was needed. From 55 scientific publications we collected 20 SNPs, which are located within 18 miRNA encoding genes and have been associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are located within the premature miRNA region, five within mature, and two within mature seed miRNA region. We graphically visualized a network of miRNA-cancer associations which revealed miRNA genes and cancer types with the highest number of connections. Our study showed that, despite a large number of variations currently known to be located within miRNA genes in humans, most of them have not yet been tested for association with cancer. MicroRNA SNPs collected in this study represent only 0.43% of known miRNA gene variations (20/4687). Results of the present study will be useful to researchers investigating the clinical use of miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic targets.

• Jezik: Angleški jezik
• Ključne besede: microRNA (miRNA), cancer, single nucleotide polymorphisms (SNP)
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2015
• Št. strani: Str. 1806-1814
• Številčenje: Vol. 7, iss. 3
• PID: 20.500.12556/RUL-82543
• UDK: 575:616
• ISSN pri članku: 2072-6694
• DOI: 10.3390/cancers7030863
• COBISS.SI-ID: 3609992
• Datum objave v RUL: 25.05.2016

Gradivo je del revije

• Naslov: Cancers
• Skrajšan naslov: Cancers
• Založnik: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 09.09.2015

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: molekularna genetika, mikro RNK, polimorfizem, medicina, rak

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0220
• Naslov: Primerjalna genomika in genomska biodiverziteta

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: Z4-6807
• Naslov: Razvoj bioinformacijskih orodij za odkrivanje genetskih biooznačevalcev za nalaganje maščobe pri sesalcih