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DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity
Laplante, Mathieu (Avtor), Horvat, Simon (Avtor), Festuccia, William T. (Avtor), Birsoy, Kivanc (Avtor), Prevoršek, Zala (Avtor), Efeyan, Alejo (Avtor), Sabatini, David M. (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://dx.doi.org/10.1016/j.cmet.2012.07.008 Povezava se odpre v novem oknu

Izvleček
DEP domain-containig mTOR-interacting protein (DEPTOR) inhibits the mechanistic target of rapamty-cin (mTOR), but its in vivo functions are unknown. Previous work indicates that Deptor is part of the Fob3a quantitative trait locus (QTL) linked to obesity/leanness in mice, with Deptor expression being elevated in white adipose tissue (WAT) of obese animals. This relation is unexpected, considering the positive role of mTOR inadipogenesis. Here, we dissected the Fob3a QTL and show that Deptor is the highest-priority candidate promoting WAT expansion in this model. Consistently, transgenic mice overexpressing DEPTOR accumulate more WAT. Furthermore, in humans, DEPTOR expression in WAT correlates with the degree ofobesity. We show that DEPTOR is induced by glucocrtioids during adipogenesisand that its overexpression promotes, while its suppression blocks, adipogenesis. DEPTOR activates the proadipogenic Akt/PKB-PRAR-[ni] axisby dampening mTORC1-mediated feedback inhibition of insulin signaling. These results establish DEPTOR as a new regulator of adipogenesis.

Jezik:Angleški jezik
Ključne besede:molekularna genetika, debelost, DEPTOR
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Leto izida:2012
Št. strani:str. 202-212
Številčenje:Vol. 16, no. 2
UDK:575
ISSN pri članku:1550-4131
DOI:10.1016/j.cmet.2012.07.008 Povezava se odpre v novem oknu
COBISS.SI-ID:3085960 Povezava se odpre v novem oknu
Število ogledov:604
Število prenosov:132
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Cell metabolism
Založnik:Cell Press
ISSN:1550-4131
COBISS.SI-ID:2855188 Povezava se odpre v novem oknu

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