20.500.12556/RUL-36571
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity
DEP domain-containig mTOR-interacting protein (DEPTOR) inhibits the mechanistic target of rapamty-cin (mTOR), but its in vivo functions are unknown. Previous work indicates that Deptor is part of the Fob3a quantitative trait locus (QTL) linked to obesity/leanness in mice, with Deptor expression being elevated in white adipose tissue (WAT) of obese animals. This relation is unexpected, considering the positive role of mTOR inadipogenesis. Here, we dissected the Fob3a QTL and show that Deptor is the highest-priority candidate promoting WAT expansion in this model. Consistently, transgenic mice overexpressing DEPTOR accumulate more WAT. Furthermore, in humans, DEPTOR expression in WAT correlates with the degree ofobesity. We show that DEPTOR is induced by glucocrtioids during adipogenesisand that its overexpression promotes, while its suppression blocks, adipogenesis. DEPTOR activates the proadipogenic Akt/PKB-PRAR-[ni] axisby dampening mTORC1-mediated feedback inhibition of insulin signaling. These results establish DEPTOR as a new regulator of adipogenesis.
molekularna genetika
debelost
DEPTOR
true
false
false
Angleški jezik
Angleški jezik
Delo ni kategorizirano
2015-07-10 12:30:37
2015-07-10 12:30:37
2022-06-23 03:49:55
0000-00-00 00:00:00
2012
0
0
Str. 202-212
no. 2
Vol. 16
2012
0000-00-00
NiDoloceno
NiDoloceno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
575
1550-4131
10.1016/j.cmet.2012.07.008
3085960
2855188
http://dx.doi.org/10.1016/j.cmet.2012.07.008
1
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=36582
Biotehniška fakulteta
0
0
0