izpis_h1_title_alt

The glypican 3-hosted murine Mir717 gene : sequence conservation, seed region polymorphisms and putative targets
ID Kunej, Tanja (Avtor), ID Jevšinek Skok, Daša (Avtor), ID Horvat, Simon (Avtor), ID Dovč, Peter (Avtor), ID Jiang, Zhihua (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.biolsci.org/v06p0769.pdf Povezava se odpre v novem oknu

Izvleček
Mir717 (mmu-mir-717) was first reported in mouse and resides in the intron 3 of glypican 3 )Gpc3) gene. Our present study revealed that this microRNA (miRNA) gene is conserved among 26 mammalian species and harbors polymorphic sites within the mature seed region in mice. Our findiong represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature RNA seed sibgle nucleotide polymorphism (SNP) identified in the lean mouse strain 129/Sv. Additionally, genes potentialy targeted by Mir717 include 91 genes associated with obesity and realted phenbotypes in mammals. Our analaysis provides a basis for further experiments to casually connect the identified SNP and Mir717 gene itself to obesity regulation. Furthermore, our bioinformatics analysis now enables functional annotation of Mir717 orthologs in other species, thus determining the effect of its target genes on fat-related traits.

Jezik:Angleški jezik
Ključne besede:molekularna genetika, geni, Mir717
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Leto izida:2010
Št. strani:Str. 769-772
Številčenje:Vol. 6, no.7
PID:20.500.12556/RUL-32833 Povezava se odpre v novem oknu
UDK:575
COBISS.SI-ID:2780808 Povezava se odpre v novem oknu
Datum objave v RUL:10.07.2015
Število ogledov:1750
Število prenosov:274
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