SARS-CoV-2 vaccination and clinical presentation of COVID-19 in patients hospitalized during the delta- and omicron-predominant periods

Stupica, Daša (avtor), Collinet-Adler, Stefan (avtor), Kejžar, Nataša (avtor), Poljak, Mario (avtor), Štamol, Tina (avtor)

Evidence suggests that monovalent vaccine formulations are less effective against the Omicron SARS-CoV-2 than against previous variants. In this retrospective cohort study of hospitalized adults with PCR-confirmed COVID-19 during the Delta (October-November 2021) and Omicron (January-April 2022) variant predominant periods in Slovenia, we assessed the association between primary vaccination against SARS-CoV-2 and progression to critically severe disease (mechanical ventilation or death). Compared with the 529 patients hospitalized for acute COVID-19 during the Delta period (median age 65 years; 58.4% men), the 407 patients hospitalized during the Omicron period (median age 75 years; 50.6% men) were older, more often resided in long-term care facilities, and had higher Charlson comorbidity index scores. After adjusting for age, sex, the Charlson comorbidity index, the presence of immunocompromising conditions, and vaccination status, the patients admitted during the Omicron period had comparable odds of progressing to critically severe disease to those admitted during the Delta period. The 334/936 (35.7%) patients completing at least primary vaccination had lower odds of progression to critically severe disease and shorter hospital stay than unvaccinated patients; however, the protective effect of vaccination was less pronounced during the Omicron than during the Delta period. Although the Omicron variant appeared to better evade immunity induced by monovalent vaccines than the Delta variant, vaccination against SARS-CoV-2 remained an effective intervention to decrease morbidity and mortality in COVID-19 patients infected with the Omicron variant.

• Jezik: Angleški jezik
• Ključne besede: COVID-19 vaccine, SARS-CoV-2 antibodies, vaccine breakthrough
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 13 str.
• Številčenje: Vol. 12, iss. 3
• PID: 20.500.12556/RUL-189849
• UDK: 616.9
• ISSN pri članku: 2077-0383
• DOI: 10.3390/jcm12030961
• COBISS.SI-ID: 141887491
• Datum objave v RUL: 19.10.2026

Gradivo je del revije

• Naslov: Journal of clinical medicine
• Skrajšan naslov: J. clin. med.
• Založnik: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: cepivo za covid-19, protitelesa SARS-CoV-2, preboj cepiva

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0154
• Naslov: Metodologija za analizo podatkov v medicini

• Financer: University Medical Centre Ljubljana, Slovenia
• Številka projekta: TP20220153