Short-term BMI-SDS change during child and adolescent psychiatric hospitalization : associations with antipsychotic treatment and length of stay

Švigelj, Marjetka (avtor), Drobnič Radobuljac, Maja (avtor), Plemeniti Tololeski, Barbara (avtor), Turin, Anja (avtor), Kotnik, Primož (avtor)

Children and adolescents receiving inpatient psychiatric treatment may be at increased risk of short-term weight gain-related changes, particularly during antipsychotic exposure. In this retrospective cohort study we analyzed a patient-level cohort of 776 unique patients younger than 18 years treated between 2022 and 2024, after exclusion of eating disorder diagnoses and repeated hospitalizations. Clinical data were extracted from electronic medical records and included demographic and clinical characteristics, antipsychotic treatment, and anthropometric measurements. The median hospitalization duration was 3.0 days (IQR 2.0-7.0). Repeated BMI-SDS measurements permitting calculation of BMI-SDS change were available for 228 patients. Mean BMI-SDS change was +0.071 (SD = 0.242). BMI-SDS increased significantly among patients exposed to antipsychotics (n = 152; mean change +0.107, p < 0.001), whereas no significant change was observed among patients without antipsychotic exposure (n = 76). BMI-SDS change differed across antipsychotic treatment groups (Kruskal-Wallis p = 0.0006; ϵ² = 0.081). However, olanzapine monotherapy was not significantly different from no antipsychotic treatment after correction for multiple comparisons, although exploratory analysis showed a higher risk of BMI-SDS increase ≥0.5 with olanzapine exposure (NNH = 3.7, 95% CI 2.2–10.2). In multivariable linear regression analysis, longer hospitalization (B = 0.0035 per day, 95% CI 0.002-0.005, p < 0.001) and any antipsychotic exposure (B = 0.0668, 95% CI 0.003-0.131, p = 0.042) were associated with higher follow-up BMI-SDS after adjustment for baseline BMI-SDS. Sex, age and F20-F29 diagnosis were not significantly associated with follow-up BMI-SDS. These findings suggest that short-term BMI-SDS change during child and adolescent psychiatric hospitalization is associated with antipsychotic treatment and length of hospitalization. The results do not support a significant olanzapine dose-response relationship and should be interpreted as anthropometric associations rather than evidence of metabolic dysfunction or causality.

• Jezik: Angleški jezik
• Ključne besede: antipsychotics, BMI-SDS, child and adolescent psychiatry, olanzapine, pediatric psychopharmacology, psychiatric hospitalization, weight gain
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 9 str.
• Številčenje: Vol. 17, art. 1942502
• PID: 20.500.12556/RUL-189798
• UDK: 616.89:615.2
• ISSN pri članku: 1664-0640
• DOI: 10.3389/fpsyt.2026.1942502
• COBISS.SI-ID: 300584707
• Datum objave v RUL: 16.10.2026

Gradivo je del revije

• Naslov: Frontiers in psychiatry
• Skrajšan naslov: Front. psychiatry
• Založnik: Frontiers media
• ISSN: 1664-0640
• COBISS.SI-ID: 54153314

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: antipsihotiki, standardni odklon indeksa telesne mase, otroška in mladostniška psihiatrija, olanzapin, pediatrična psihofarmakologija, psihiatrična hospitalizacija, pridobivanje telesne mase

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0343
• Naslov: Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

• Financer: University Psychiatric Clinic Ljubljana
• Številka projekta: TerP-UPKL-2026/08