Introduction: Sjӧgren's syndrome is a systemic rheumatic disease that affects the exocrine glands. In addition to the characteristic dryness of the mucous membranes, it can cause pain and inflammation of the muscles and joints, as well as damage to the nervous system and internal organs. Individuals often experience pain, fatigue, and sleep disturbances. Due to the less visible nature of their symptoms, they are often misunderstood and overlooked by society. Effective symptom management and the development of strategies to support everyday functioning can significantly improve their quality of life. Purpose: The purpose of this thesis was to identify personal and environmental factors that affect two individuals with Sjӧgren's syndrome and analyse how these factors affect their performance of everyday occupations. Moreover, we aimed to explore how they cope with these challenges, and examine the role of occupational therapy in addressing them. Methods: A two-case study was conducted. To explore the role of occupational therapy, an interview was also conducted with an occupational therapist. The collected data were analysed using qualitative content analysis, combining both inductive and deductive approaches. Results: Using a deductive approach based on the PEOP model, the codes were classified into four categories: personal factors, environmental factors, occupation, and occupational performance. To explore the role of occupational therapy, the following categories were developed through an inductive approach: session evaluation and planning, interventions and factors influencing the process of occupational therapy. The findings showed that, despite the same diagnosis, the two individuals face different personal and environmental factors, which results in different experiences of occupational performance. Over time and with the support of an occupational therapist, they have developed different strategies to overcome these challenges. Discussion and conclusion: In accordance with the existing literature, the two individuals in our study face challenges in all areas of occupation. Physical strain and reduced effectiveness have been detected in occupational performance, compelling them to adapt their performance with assistive devices and modified ways of performing activities. This is where participation in occupational therapy plays a significant role. However, we have identified a lack of specific assessments and interventions in occupational therapy for individuals with Sjӧgren's syndrome. Our findings thereby provide a basis for further research and the development of coherent guidelines for clinical practice that could improve the quality of life of individuals with Sjӧgren's syndrome.
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