Smoking and diabetes attenuate number of CD34$^{+}$ haematopoietic stem cells in peripheral blood of patients with advanced peripheral artery disease

Šernek, Barbara (avtor), Kamnikar, Rok (avtor), Šebeštjen, Miran (avtor), Boc, Anja (avtor), Boc, Vinko (avtor)

Peripheral artery disease (PAD) is a globally prevalent problem with limited treatment options, leaving up to a fifth of patients remediless. The emergence of new studies on cell therapy in recent years offers a new promising option for their treatment. Our aim was to explore how the number of CD34$^{+}$ hematopoietic cells in the peripheral blood of PAD patients is associated with patients’ functional as well as atherogenic factors. We selected 30 patients with advanced PAD, recorded their performance in a walking test in standard conditions and sampled their blood for further analysis with an emphasis on CD34$^{+}$ cell selection and counting. No correlation of the CD34$^{+}$ cell number was confirmed with any of the observed laboratory parameters. There was an association between the claudication distance and the number of CD34$^{+}$ cells (r = −0.403, p = 0.046). The number of CD34$^{+}$ cells differed between patients with and without type II diabetes (p = 0.071) and between active smokers, past smokers, and non-smokers (p = 0.035; p = 0.068, p = 0.051, respectively), with both smoking and presence of diabetes type II having a negative effect on the number of CD34$^{+}$ cells. Our study demonstrated a dependence of the CD34$^{+}$ cell number on the patient’s characteristics.

• Jezik: Angleški jezik
• Ključne besede: CD34$^{+}$ cells, peripheral artery disease, smoking, diabetes type II, intermittent claudication
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 10 str.
• Številčenje: Vol. 24, iss. 20, art. 15346
• PID: 20.500.12556/RUL-187756
• UDK: 616.1
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms242015346
• COBISS.SI-ID: 177470723
• Datum objave v RUL: 15.09.2026

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: celice CD34$^{+}$, periferna arterijska bolezen, kajenje, sladkorna bolezen, tip 2, prekinitvena klavdikacija

Projekti

• Financer: University Medical Centre Ljubljana
• Številka projekta: TP 20180022

• Financer: University Medical Centre Ljubljana
• Številka projekta: TP 20220018