In my thesis, I compared the course of acylation of aromatic compounds between a classic Friedel–Crafts method, using acetyl chloride and aluminium trichloride in dry dichloromethane and “green” method, where the reaction is conducted in trifluoroacetic acid and with acetic anhydride. In the latter reaction, the trifluoroacetic acid is acting both as a reaction medium and catalyst. The core benefit of the green acylation is the reusability of TFA and smaller chemical waste production compared to classic acylation. In cases where reactions with green acylation were successful, the yields and complexity of further purification were comparable to classic acylation. I purified all synthesised products and analysed them with 1H NMR, IR spectroscopy and mass spectrometry.
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