In this bachelor's thesis, we investigated the Suzuki-Miyaura reaction for the functionalization of peptides in an aqueous medium using the water-soluble palladium catalyst Py-tzNHC. 4-iodo-L-phenylalanine was synthesized, protected with an Fmoc protecting group and incorporated into a peptide sequence by solid-phase peptide synthesis (SPPS). The effects of different reaction conditions, particularly catalyst loading, pH. reaction time and the choice of palladium catalyst, on the efficiency of the Suzuki-Miyaura coupling were investigated. The progress of the reactions and product formation were monitored by LC-MS analysis. Based on the obtained results, suitable reaction conditions were selected and subsequently applied to more complex peptide systems. A Suzuki-Miya ura coupling between two peptides was also successfully performed and confirmed by LC-MS analysis.
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