Sinteza 4-okso-4H-pirido[1,2-a]pirimidin-3-diazonijevega tetrafluoroborata

Koman, Jernej (avtor), Svete, Jurij (mentor)

V diplomski nalogi sem po petstopenjskem postopku iz hipurne kisline sintetiziral 4-okso-4H-pirido[1,2-a]pirimidin-3-diazonijev tetrafluoroborat, ki je uporaben intermediat v sintezi heterociklov in biokonjugaciji. Končni produkt in vse intermediate sem okarakteriziral z IR in 1H NMR spektroskopijo, štiri spojine pa tudi z elementno analizo za C, H in N. Ugotovil sem tudi, da se je spojina 3-amino-4-okso-4H-pirido[1,2-a]pirimidin ob obarjanju iz raztopine izločila v obliki dihidrokloridne soli.

• Jezik: Slovenski jezik
• Ključne besede: 4-okso-4H-pirido[1, 2-a]pirimidin-3-diazonijev tetrafluoroborat, organska sinteza, biokonjugacija, fluorescenca, diazonijeve soli
• Vrsta gradiva: Diplomsko delo/naloga
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Leto izida: 2026
• PID: 20.500.12556/RUL-186931
• Datum objave v RUL: 07.09.2026

Sekundarni jezik

• Jezik: Angleški jezik
• Naslov: Synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidin-3-diazonium tetrafluoroborate

Izvleček

In this thesis 4-oxo-4H-pyrido[1,2-a]pyrimidin-3-diazonium tetrafluoroborate, a useful intermediate in the synthesis of heterocycles and bioconjugation, was synthesized in five steps from hippuric acid. The final product and all intermediates were characterized by IR and 1H NMR spectroscopy; four out of five compounds were also characterized by elemental analysis for C, H, and N. I also found out that 3-amino-4-oxo-4H-pyrido[1,2-a]pyrimidine precipitated from the solution as a dihydrochloride salt.

• Ključne besede: 4-oxo-4H-pyrido[1, 2-a]pyrimidine-3-diazonium tetrafluoroborate, organic synthesis, bioconjugation, fluorescence, diazonium salts