Statin adherence in atherosclerotic disease : research data underlying the article

Furlan, Tjaša (avtor), Došenović Bonča, Petra (avtor), Ograjenšek, Irena (avtor), Jug, Borut (avtor)

Aims: To evaluate post-discharge statin adherence and its association with clinical outcomes after hospitalisation for atherosclerotic cardiovascular disease (ASCVD). Methods: In this nationwide Slovenian cohort, hospital, pharmacy, and vital-status data were linked for adults hospitalised with coronary artery, cerebrovascular, or peripheral artery disease between 2015 and 2022. Statin adherence was assessed as time-varying rolling 365-day proportion of days covered (PDC) and 120-day CMA7. The outcome was all-cause death or rehospitalisation for ASCVD. Results: Of 82,083 patients in the 30-day landmark cohort, 62,932 had at least one post-discharge statin dispensing. Overall, 23% had no recorded post-discharge dispensing, rising to 30% in peripheral artery disease. Higher adherence was independently associated with lower risk of the composite outcome: each 10-percentage-point increase in PDC and CMA7 was associated with a hazard ratio of 0.96 (95% CI 0.96–0.97; both p<0.001). Conclusion: Better longitudinal statin adherence was associated with lower risk of death or recurrent ASCVD hospitalisation, while substantial treatment gaps remained, particularly in peripheral artery disease.

• Jezik: Angleški jezik
• Ključne besede: atherosclerotic cardiovascular disease, statins, medication adherence, persistence, secondary prevention
• Tipologija: 2.20 - Zaključena znanstvena zbirka raziskovalnih podatkov
• Geografsko pokritje: Slovenia
• Časovno pokritje: 2015-2022
• Organizacija: MF - Medicinska fakulteta
• Leto izida: 2026
• PID: 20.500.12556/RUL-186851
• Metode zbir. podat.: Sinteza; Združevanje; Drugi
• Datum objave v RUL: 10.09.2026

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: aterosklerotična srčno-žilna bolezen, statini, adherenca k zdravljenju z zdravili, vztrajnost pri zdravljenju, sekundarna preventiva

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: V3-24038
• Naslov: Strokovna izhodišča in priporočila za oblikovanje državnega programa obvladovanja bolezni srca in ožilja v Sloveniji

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P5-0117
• Naslov: Trajnostna konkurenčnost slovenskega gospodarstva v evropskem in globalnem okviru