Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress

Goričar, Katja (avtor), Debevec, Tadej (avtor), Dolžan, Vita (avtor), Martin, Agnès (avtor), Pialoux, Vincent (avtor), Millet, Grégoire P. (avtor), Osredkar, Damjan (avtor)

Preterm born (PTB) infants are at risk for injuries related to oxidative stress. We investigated the association between antioxidant and neurodevelopmental gene polymorphisms and oxidative stress parameters in PTB male young adults and their term-born counterparts at rest and during exercise. Healthy young PTB (N= 22) and full-term (N= 15) males underwent graded exercise tests in normobaric normoxic (F$_i$O$_2$ = 0.21) and hypoxic (F$_i$O$_2$ = 0.13) conditions. CAT rs1001179 was associated with decrease in nitrites in the whole group and in PTB individuals (P= 0.017 and P= 0.043, respectively). GPX1 rs1050450 was associated with decrease in ferric reducing antioxidant power in the whole group and in full-term individuals (P= 0.017 and P= 0.021, respectively). HIF1A rs11549465 was associated with decrease in nitrotyrosine and increase in malondialdehyde (P= 0.022 and P= 0.018, respectively). NOTCH4 rs367398 was associated with increase in advanced oxidation protein products and nitrites (P= 0.002 and P= 0.004, respectively) in hypoxia. In normoxia, NOTCH4 rs367398 was associated with increase in malondialdehyde in the whole group (P= 0.043). BDNF rs6265 was associated with decreased nitrites/nitrates in the whole group and in PTB individuals (P= 0.009 and P= 0.043, respectively). Polymorphisms in investigated genes and PTB might influence oxidative stress response after exercise in normoxic or hypoxic conditions far beyond the neonatal period in young male adults.

• Jezik: Angleški jezik
• Ključne besede: sport, antioxidant, neurodevelopmental gene, prematurely born individuals, hypoxia-related oxidative stress
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FŠ - Fakulteta za šport ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 10 str.
• Številčenje: Vol. 14, art. 14956
• PID: 20.500.12556/RUL-186627
• UDK: 796:616.12-008.44
• ISSN pri članku: 2045-2322
• DOI: 10.1038/s41598-024-65647-4
• COBISS.SI-ID: 200453379
• Datum objave v RUL: 03.09.2026

Gradivo je del revije

• Naslov: Scientific reports
• Skrajšan naslov: Sci. rep.
• Založnik: Springer Nature
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: šport, antioksidanti, nevrorazvojni gen, prezgodaj rojeni, hipoksija, oksidativni stres