Exploring zinc(II) coordination chemistry with picolinate and amino alcohols : toward new antibacterial agents

Modec, Barbara (avtor), Podjed Rihtaršič, Nina (avtor), López-Serrano, Joaquín (avtor), Hrast Rambaher, Martina (avtor), Golob, Majda (avtor)

Zinc(II) coordination chemistry with picolinate (abbreviated as pic$^–$, an anion of pyridine-2-carboxylic acid) and a series of β-amino alcohols (2-aminoethanol, 2-methylaminoethanol, 2-ethylaminoethanol, 2-dimethylaminoethanol, 2-amino-1-propanol, 1-amino-2-butanol, and 1-amino-2-methyl-2-propanol) was systematically investigated. Reaction systems typically yielded complexes with the general composition [Zn(pic)$_2$(amino alcohol)] via a straightforward synthetic route. Zinc(II) adopts an octahedral coordination environment consisting of two N,O-bidentate chelating picolinates and one amino alcohol, likewise coordinated in a chelating manner through amino and hydroxyl groups. As no fac isomers were isolated, the relative stability of mer and fac isomers of the 2-methylaminoethanol complex was evaluated by DFT calculations, which supported a preference for the mer geometry. Interestingly, the 1-amino-2-methyl-2-propanol system also produced an ionic species, [Zn(pic)$_3$]$^−$, which crystallized as a salt with protonated amino alcohol. All novel compounds were characterized using infrared and $^1$H NMR spectroscopy, elemental analysis, mass spectrometry, and single-crystal X-ray diffraction. Selected tris-chelates displayed moderate antibacterial activity against S. epidermidis, with MIC values ranging from 32 to 64 μg/mL, whereas picolinic acid alone was inactive.

• Jezik: Angleški jezik
• Ključne besede: zinc(II), picolinic acid, amino alcohols, crystal structure, DFT calculations, antibacterial activity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 32955-32970
• Številčenje: Vol. 11, iss. 22
• PID: 20.500.12556/RUL-186510
• UDK: 546.47:547.435:547.82
• ISSN pri članku: 2470-1343
• DOI: 10.1021/acsomega.6c02474
• COBISS.SI-ID: 282035459
• Datum objave v RUL: 02.09.2026

Gradivo je del revije

• Naslov: ACS omega
• Skrajšan naslov: ACS omega
• Založnik: American Chemical Society
• ISSN: 2470-1343
• COBISS.SI-ID: 525873945

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: cink(II), pikolinska kislina, amino alkoholi, kristalne strukture, DFT izračuni, protibakterijsko delovanje