Anteromedial globus pallidus internus deep brain stimulation for Gilles de la Tourette syndrome : a two-case report and review of the literature

Felbabić, Tomislav (avtor), Berlot, Rok (avtor), Trošt, Maja (avtor), Georgiev, Dejan (avtor), Benedičič, Mitja (avtor)

Background: Gilles de la Tourette syndrome is a neurobehavioral disorder that typically begins in childhood, subsides during puberty, and may reappear in adolescence. Treatment is primarily conservative, involving psychological and pharmacological therapy. Patients who do not respond to conservative therapy may be treated with deep brain stimulation, although this remains an experimental treatment. Methods: In this two-case report we present the first two cases of patients with Gilles de la Tourette syndrome in Slovenia treated with deep brain stimulation of the anteromedial globus pallidus internus. Results: Over an 18-month follow-up period, we observed an improvement in both cases. In the first case, the Yale Global Tic Severity Scale score decreased from 71 (17 for motor tics, 14 for phonic tics, and 40 on the impairment scale) to 44 points (12 motor, 12 phonic, and 20 impairment). In the second case, the score decreased from 72 (16 motor, 16 phonic, and 40 impairment) to 38 points (8 motor, 10 phonic, and 20 impairment). Conclusions: Deep brain stimulation could be a promising treatment for this disorder. However, further research is needed to determine the most suitable patients and targets.

• Jezik: Angleški jezik
• Ključne besede: deep brain stimulation, Gilles de la Tourette syndrome, anteromedial globus pallidus internus
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Drugi znanstveni članki
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 9 str.
• Številčenje: Vol. 18, iss. 2, art. 21
• PID: 20.500.12556/RUL-186344
• UDK: 616.8
• ISSN pri članku: 2035-8377
• DOI: 10.3390/neurolint18020021
• COBISS.SI-ID: 266297091
• Datum objave v RUL: 31.08.2026

Gradivo je del revije

• Naslov: Neurology international
• Skrajšan naslov: Neurol. int.
• Založnik: MDPI
• ISSN: 2035-8377
• COBISS.SI-ID: 517576217

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: globoka možganska stimulacija, sindrom Gilles de la Tourette, anteromedialni del globus pallidus internus