Celjenje razjed na diabetičnem stopalu pri zdravljenju s trombocitno plazmo : diplomsko delo

Miklavc, Maria Victoria (avtor), Pajnič, Manca (mentor), Birk Tot, Karin (komentor), Matić, Lucija (recenzent)

Uvod: Svetovna razširjenost sladkorne bolezni je v letu 2024 dosegla 589 milijonov odraslih, ob tem pa se podaljšuje življenjska doba pacientov. To je privedlo do povečane incidence razjed diabetičnega stopala, ki se pojavljajo pri 19–34 % pacientov s sladkorno boleznijo. Trenutno standardno zdravljenje razjed diabetičnega stopala vključuje nadzor glukoze v krvi, razbremenitev pritiska, uporabo ustrezne obutve in oskrbo ran. V zadnjih letih se kot dodatna terapevtska možnost za zdravljenje razjed na diabetičnem stopalu pojavlja terapija s trombocitno plazmo. Namen: Namen diplomskega dela je predstaviti celjenje razjed na diabetičnem stopalu z uporabo trombocitne plazme. Poleg tega želimo analizirati ugotovitve znanstvene literature o uporabi te metode in stopnji zapletov, povezanih z njeno uporabo, ter analizirati možno vlogo zdravstvene nege pri zdravljenju razjed na diabetičnem stopalu s to metodo na podlagi obstoječih kompetenc diplomiranih medicinskih sester. Metode dela: V diplomskem delu smo uporabili deskriptivno metodo pregleda literature za obdobje od leta 2017 do leta 2026. Iskanje literature je potekalo v angleškem in španskem jeziku v bibliografskih podatkovnih bazah COBISS, CINAHL, MEDLINE, EBSCO in Google Scholar. V analizo smo vključili 12 člankov. Rezultati: Vključene raziskave so pokazale pozitivne učinke uporabe trombocitne plazme. V raziskavah, kjer so primerjali to metodo s standardno oskrbo, je bilo celjenje ran v intervencijskih skupinah hitrejše, učinkovitost zdravljenja pa višja. V raziskavah brez kontrolnih skupin so bili rezultati podobni. Poročanih zapletov, povezanih z uporabo trombocitne plazme, ni bilo. Podatki o vlogi zdravstvene nege pri zdravljenju s trombocitno plazmo so bili omejeni, saj aktivnosti medicinskih sester v vključenih raziskavah niso bile jasno opredeljene. Razprava in zaključek: Pregled literature kaže, da je trombocitna plazma učinkovita in varna dodatna metoda zdravljenja razjed na diabetičnem stopalu, saj pospešuje celjenje ran in je povezana z nizko stopnjo zapletov. Odločanje o diagnostiki in zdravljenju razjed na diabetičnem stopalu ostaja v pristojnosti zdravnika, vendar lahko diplomirane medicinske sestre v okviru svojih kompetenc sodelujejo pri obravnavi pacientov. Njihova vloga pri zdravljenju s trombocitno plazmo v analiziranih raziskavah ni bila jasno opredeljena.

• Jezik: Slovenski jezik
• Ključne besede: diplomska dela, zdravstvena nega, kronična rana, sladkorna bolezen, plazma obogatena s trombociti, oskrba ran, vloga medicinske sestre
• Vrsta gradiva: Diplomsko delo/naloga
• Tipologija: 2.11 - Diplomsko delo
• Organizacija: ZF - Zdravstvena fakulteta
• Kraj izida: Ljubljana
• Založnik: [M. V. Miklavc]
• Leto izida: 2026
• Št. strani: 26 str.
• PID: 20.500.12556/RUL-186259
• UDK: 616-083
• COBISS.SI-ID: 289390595
• Datum objave v RUL: 29.08.2026

Sekundarni jezik

• Jezik: Angleški jezik
• Naslov: Treatment of diabetic foot ulcers with platelet-rich plasma : diploma work

Izvleček

Introduction: In 2024, the global prevalence of diabetes mellitus reached 589 million adults, while life expectancy of patients continues to increase. This has contributed to a higher incidence of diabetic foot ulcers, which occur in 19–34% of patients with diabetes. Current standard treatment of diabetic foot ulcers includes blood glucose control, pressure offloading, appropriate footwear, and wound care. In recent years, platelet-rich plasma therapy has emerged as an additional therapeutic option for the treatment of diabetic foot ulcers. Purpose: The aim of the thesis was to present the healing of diabetic foot ulcers using platelet-rich plasma. In addition, the aim was to analyse findings from scientific literature regarding the use of this method, the rate of complications associated with its use, and the possible role of nursing care in the treatment of diabetic foot ulcers with this method based on the existing competencies of registered nurses. Methods: A descriptive literature review method was used for the period from 2017 to 2026. The literature search was conducted in English and Spanish using the bibliographic databases COBISS, CINAHL, MEDLINE, EBSCO, and Google Scholar. Twelve articles were included in the analysis. Results: The included studies demonstrated positive effects of platelet-rich plasma use. In studies comparing this method with standard care, wound healing was faster and treatment effectiveness was higher in intervention groups. Similar results were reported in studies without control groups. No complications associated with the use of platelet-rich plasma were reported. Data regarding the role of nursing care in treatment with platelet-rich plasma were limited, as nursing activities were not clearly defined in the included studies. Discussion and conclusion: The literature review indicates that platelet-rich plasma is an effective and safe additional treatment method for diabetic foot ulcers, as it promotes wound healing and is associated with a low rate of complications. Decisions regarding the diagnosis and treatment of diabetic foot ulcers remain within the physician’s scope of practice; however, registered nurses can participate in patient care within their competencies. Their role in treatment with platelet-rich plasma was not clearly defined in the analysed studies.

• Ključne besede: diploma theses, nursing care, chronic wound, diabetes mellitus, platelet-rich plasma, wound care, nursing role