Monoclonal annular lichenoid dermatitis of youth as a new entity : a case report and review of the literature

Točkova, Olga (avtor), Hosta, Violeta (avtor), Planinšek Ručigaj, Tanja (avtor), Ponorac, Svjetlana (avtor), Koković, Ira (avtor), Calonje, Eduardo (avtor), Luzar, Boštjan (avtor)

Annular lichenoid dermatitis of youth (ALDY) is a rare lichenoid dermatosis characterized by distinctive clinical and histopathological features. Its etiopathogenesis remains poorly understood, and previously reported cases have consistently demonstrated polyclonal T-cell receptor (TCR) gene rearrangements. We report a patient with clinical, histopathological, and immunohistochemical findings consistent with ALDY in whom molecular analysis revealed monoclonal T-cell receptor rearrangement within the skin lesions. To our knowledge, this represents the first reported case of ALDY demonstrating T-cell monoclonality. This novel finding expands the current understanding of the molecular spectrum of ALDY and raises the possibility that cases with monoclonal T-cell rearrangement may represent a distinct clinicopathological variant. Based on our findings, we tentatively propose the term monoclonal annular lichenoid dermatitis of youth (MALDY) to describe this potential entity. Further studies are warranted to clarify its clinical significance and relationship to other cutaneous T-cell disorders.

• Jezik: Angleški jezik
• Ključne besede: T-cell monoclonality, annular lichenoid dermatosis, youth, cutaneous T-cell lymphoma, dermatopathology
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 12 str.
• Številčenje: Vol. 27, iss. 9, art. 3990
• PID: 20.500.12556/RUL-185868
• UDK: 61
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms27093990
• COBISS.SI-ID: 276799235
• Datum objave v RUL: 21.08.2026

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.