Left bundle branch area pacing vs right ventricular pacing for atrioventricular block : the MELOS RELOADED study

Jastrzębski, Marek (avtor), Kiełbasa, Grzegorz (avtor), Cano, Oscar (avtor), Curila, Karol (avtor), Zanon, Francesco (avtor), Žižek, David (avtor)

Background and Aims: Left bundle branch area pacing (LBBAP) promotes physiological synchronous activation of the left ventricle and may be particularly beneficial in patients with atrioventricular block (AVB), but its mortality benefit remains unclear. This study aims to compare long-term survival in AVB patients receiving either LBBAP or right ventricular pacing (RVP) and to analyse predictors of mortality during LBBAP. Methods: MELOS RELOADED, a multicentre European collaboration, was a registry-based study of pacemaker patients with AVB, left ventricular ejection fraction (LVEF) >40% and ventricular pacing >20%. The primary outcome was all-cause mortality based on national registries. A 1:1 propensity score matching was performed between the RVP and LBBAP groups. Kaplan–Meier curves and multivariable Cox proportional hazards models were used to estimate survival. Results: In total, 3382 patients receiving LBBAP or RVP were matched. At 4-year follow-up, the Kaplan–Meier curve showed an absolute difference in survival of 11.8% in favour of LBBAP (P < .001). LBBAP was a robust predictor of reduced mortality with a hazard ratio (HR) of 0.53 (95% confidence interval 0.42–0.65, P < .001). Within the LBBAP group, the following independent predictors of increased mortality were identified: lack of confirmed left bundle branch capture (HR 1.85, P < .001), lower percentage of ventricular pacing (HR 1.12), and age. Conclusions: This is the first large study demonstrating the long-term survival benefit of LBBAP. This strengthens the use of LBBAP in AVB patients with preserved/mildly reduced LVEF while awaiting the results of randomized trials. Confirmation of left bundle branch capture seems advisable to achieve optimal results with LBBAP.

• Jezik: Angleški jezik
• Ključne besede: conduction system pacing, left bundle branch area pacing, atrioventricular block, mortality, heart failure
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.01.2026
• Leto izida: 2026
• Št. strani: Str. 1541–1550
• Številčenje: Vol. 47, iss. 13
• PID: 20.500.12556/RUL-185273
• UDK: 616.1
• ISSN pri članku: 1522-9645
• DOI: 10.1093/eurheartj/ehaf699
• COBISS.SI-ID: 258710019
• Datum objave v RUL: 30.07.2026

Gradivo je del revije

• Naslov: European heart journal
• Skrajšan naslov: Eur. heart j.
• Založnik: Oxford University Press, Eureopan Society of Cardiology
• ISSN: 1522-9645
• COBISS.SI-ID: 515374105

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.