Preventing regrettable substitutions : a proposal for a tiered testing approach for BPA alternatives under the PARC initiative

Aiello, Kiara (avtor), Bartmann, Kristina (avtor), Buratti, Franca Maria (avtor), Cabaton, Nicolas J. (avtor), Coppola, Lucia (avtor), Corsini, Emanuela (avtor), De La Vieja, Antonio (avtor), Franko, Nina (avtor), Kodila, Anja (avtor), Sollner Dolenc, Marija (avtor)

Bisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.

• Jezik: Angleški jezik
• Ključne besede: bisphenol A alternatives, carcinogenicity, developmental neurotoxicity (DNT, endocrine disruption (ED), human hazard assessment, immunotoxicity, metabolism, new approach methodologies (NAMs)
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 9 str.
• Številčenje: Vol. 8
• PID: 20.500.12556/RUL-184522
• UDK: 615.9+616.43-008.6
• ISSN pri članku: 2673-3080
• DOI: 10.3389/ftox.2026.1815869
• COBISS.SI-ID: 284130051
• Datum objave v RUL: 09.07.2026

Gradivo je del revije

• Naslov: Frontiers in toxicology
• Skrajšan naslov: Front. toxicol.
• Založnik: Frontiers Media
• ISSN: 2673-3080
• COBISS.SI-ID: 68385795

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: alternative bisfenolu A, kancerogenost, razvojna nevrotoksičnost (DNT), endokrine motnje (ED), ocena nevarnosti za ljudi, imunotoksičnost, metabolizem, metodologije novega pristopa (NAMs), hormonske motnje, toksikologija

Projekti

• Financer: EC - European Commission
• Številka projekta: 101057014
• Naslov: Partnership for the Assessment of Risks from Chemicals
• Akronim: PARC