Can intermittent hypoxic conditioning enhance the benefits of standard long COVID-19 rehabilitation?

Kambič, Tim (avtor), Debevec, Tadej (avtor), Lainščak, Mitja (avtor)

Background: Cachexia is a frequent companion of chronic diseases and a well-established predictor of poor patient perfor- mance and outcome. Since cachexia as a discharge diagnosis is not much investigated, we aimed to investigate prevalence of cachexia in hospitalised patients and their outcome. Methods: We conducted a retrospective analysis of the National Hospital Health Care Statistics Database using the 10th revision of the International Classification of Diseases codes. During period 2004–2019, patients with cachexia were identified, as well as patients with cancer, heart failure, chronic obstructive pulmonary disease and chronic kidney disease. The primary endpoint was the discharge code of cachexia; secondary endpoints were length of hospital stay, in-hospital and post discharge all-cause mortality. Results: In period 2004–2019, 5 484 103 hospitalisations were screened; cachexia was coded 19 348 times (0.35%) in 14 089 pa- tients (67 ± 13 years, 42% women). From 2004 to 2019, prevalence of cachexia increased steadily from 1.2% to 1.9%, which was most prominent for cancer and chronic obstructive pulmonary disease. At one year post discharge, 49% patients with cachexia were dead as compared to 26% in patients without cachexia. In Cox multivariate analysis, cachexia predicted post- discharge death in any of chronic diseases (hazard ratio of 1.28 in heart failure to 1.47 in chronic kidney disease). Conclusions: In our report from a National Hospital Health Care Statistics Database, we found that cachexia was underreported as ICD-10 coded discharge diagnosis in patients with chronic diseases. When diagnosed, it was associated with higher hazard of post discharge mortality.

• Jezik: Angleški jezik
• Ključne besede: exercise training, hypoxia exposure, post COVID-19, pulmonary rehabilitation, SARS-CoV-2
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Drugi znanstveni članki
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 4 str.
• Številčenje: art. e13769, Vol 16
• PID: 20.500.12556/RUL-182864
• UDK: 616.12-008.44:616.98:578.834 :796
• ISSN pri članku: 2190-6009
• DOI: 10.1002/jcsm.13769
• COBISS.SI-ID: 228241667
• Datum objave v RUL: 26.05.2026

Gradivo je del revije

• Naslov: Journal of cachexia, sarcopenia and muscle
• Skrajšan naslov: J. cachexia sarcopenia muscle
• Založnik: Wiley
• ISSN: 2190-6009
• COBISS.SI-ID: 522763289

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: trening vadbe, izpostavljenost hipoksiji, po COVID-19, pljučna rehabilitacija, SARS-CoV-2

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P5-0147
• Naslov: Kineziologija monostrukturnih, polistrukturnih in konvencionalnih športov

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0456
• Naslov: Celostna obravnava srčnega popuščanja v Sloveniji: od epidemiologije do kliničnih raziskav