The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme : BRAVE study

Mekjavić, Igor B. (author), Sorrentino, Riccardo (author), Fortune, Jack (author), Fisher, Jason T. (author), Tsoutsoubi, Lydia (author), Ioannou, Leonidas G. (author), Vovk, Andrej (author), Supej, Matej (author), McDonnell, Adam (author), Ciuha, Urša (author)

We evaluated the feasibility and efficacy of a 2-week training programme comprising resistance vibration exercise (RVE) without and with artificial gravity (AG). Participants (n = 24) were divided into three groups: (i) URVE: upright loaded squat exercise; (ii) HRVE: horizontal loaded squat exercise; and (iii) AGRVE: loaded squat exercise conducted on a short-arm human centrifuge. All participants followed the same protocol and were exposed to the same ground reaction force, whilst performing exercise comprising bilateral squats, triple extension squats and single/bilateral calf raises. Before and after the 2-week training period, we measured thigh and calf muscle strength with isokinetic dynamometry, muscular power with a jump test, volume with functional muscle magnetic resonance imaging, and body composition with dual-energy X-ray absorptiometry. All groups showed significant improvements in eight-repetition maximum squat strength (P < 0.0001, G > 0.80), whilst only the AGRVE group demonstrated a small effect in jump height (G=0.26). The AGRVE group significantly increased knee extension and flexion maximum voluntary contraction (MVC), with no comparable changes in the HRVE or URVE groups. The AGRVE group increased total thigh muscle volume (P = 0.03), with notable hypertrophy in the vastus medialis, semitendinosus, and vastus intermedius muscles. These findings demonstrate that AGRVE is significantly superior to HRVE and URVE in enhancing knee MVC and thigh muscle volume, thus indicating that artificial gravity improves the outcome of resistance vibration exercise in ambulatory participants.

• Language: English
• Keywords: exercise physiology, artificial gravity, muscle strength, resistance vibration exercise
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FŠ - Faculty of Sport; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2026
• Number of pages: Str. 1165-1180
• Numbering: Vol. 111, iss. 3
• PID: 20.500.12556/RUL-182700
• UDC: 612
• ISSN on article: 1469-445X
• DOI: 10.1113/EP093066
• COBISS.SI-ID: 260931331
• Publication date in RUL: 21.05.2026

Record is a part of a journal

• Title: Experimental physiology
• Shortened title: Exp. physiol.
• Publisher: Wiley
• ISSN: 1469-445X
• COBISS.SI-ID: 517708569

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: umetna gravitacija, mišična moč, telovadba, fiziologija

Projects

• Funder: ESA - European Space Agency
• Funding programme: European Space Agency
• Project number: 4000138718/22/NL/DB

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P2-0076
• Name: Avtomatika, Robotika in Biokibernetika