Silane-modified lanthanide complexes for integration into hybrid coatings and nanoparticles : thermal sensing applications and live cell labeling

Sedmak, Ivan (avtor), Bolje, Aljoša (avtor), Kljun, Jakob (avtor), Podlipec, Rok (avtor), Kokot, Hana (avtor), Nemec, Sebastjan (avtor), Kralj, Slavko (avtor), Rodič, Peter (avtor), Golobič, Iztok (avtor), Pajk, Stane (avtor)

Temperature sensing at the micro- and nanoscale remains a significant challenge due to the limitations of conventional techniques in spatial resolution and invasiveness. Here, we report the development of luminescent, temperature-sensitive coatings and nanoparticles based on a newly synthesized europium (Eu) complex integrated into a composite poly(methyl methacrylate)-siloxane-silica (PMMA-siloxane silica) matrix. The Eu complex, identified as the most promising candidate among three lanthanide complexes, was functionalized with silyl ethers via copper-catalyzed azide-alkyne cycloaddition and successfully incorporated into thin PMMA-siloxane silica films on glass surfaces and within silica nanoparticles. These materials exhibited strong thermal responsiveness, chemical stability, and suitability for high-resolution temperature sensing. Furthermore, Eu-loaded silica nanoparticles showed a distinct fluorescent signal and multiplexing capability in live-cell confocal microscopy and were internalized by lung epithelial cells (LA-4 cell line), highlighting their potential as bioimaging probes for localized intracellular temperature sensing. Although some photobleaching was observed under prolonged excitation, the materials demonstrated sufficient chemical and mechanical stability, making them promising for luminescent temperature sensing and live-cell imaging. These results establish the developed Eu-based hybrid materials as robust, non-invasive luminescent probes for high-resolution thermal sensing and cellular imaging.

• Jezik: Angleški jezik
• Ključne besede: temperature sensing, silica nanoparticles, europium complex, Eu complex, photostability, PMMA-siloxane silica coating, thermometry, photostability
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FS - Fakulteta za strojništvo ; FFA - Fakulteta za farmacijo ; FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 13 str.
• Številčenje: Vol. 589, art. 122904
• PID: 20.500.12556/RUL-182668
• UDK: 621.7+621.9
• ISSN pri članku: 1873-3255
• DOI: 10.1016/j.ica.2025.122904
• COBISS.SI-ID: 250457603
• Datum objave v RUL: 20.05.2026

Gradivo je del revije

• Naslov: Inorganica Chimica Acta
• Založnik: Elsevier
• ISSN: 1873-3255
• COBISS.SI-ID: 23179013

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: senzorji, zaznavanja temperature, nanodelci v matrici silike, nanodelci