Ferric carboxymaltose and exercise capacity in heart failure with preserved ejection fraction and iron deficiency : the FAIR-HFpEF trial

Haehling, Stephan (avtor), Lainščak, Mitja (avtor)

Background and aims: Evidence is lacking that correcting iron deficiency (ID) has clinically important benefits for patients with heart failure with preserved ejection fraction (HFpEF). Methods: FAIR-HFpEF was a multicentre, randomized, double-blind trial designed to compare intravenous ferric carboxymaltose (FCM) with placebo (saline) in 200 patients with symptomatic HFpEF and ID (serum ferritin < 100 ng/mL or ferritin 100-299 ng/mL with transferrin saturation < 20%). The primary endpoint was change in 6-min walking test distance (6MWTD) from baseline to week 24. Secondary endpoints included changes in New York Heart Association class, patient global assessment, and health-related quality of life (QoL). Results: The trial was stopped because of slow recruitment after 39 patients had been included (median age 80 years, 62% women). The change in 6MWTD from baseline to week 24 was greater for those assigned to FCM compared to placebo [least square mean difference 49 m, 95% confidence interval (CI) 5-93; P = .029]. Changes in secondary endpoints were not significantly different between groups. The total number of adverse events (76 vs. 114) and serious adverse events (5 vs. 19; rate ratio 0.27, 95% CI 0.07-0.96; P = .043) was lower with FCM than placebo. Conclusions: In patients with HFpEF and markers of ID, intravenous FCM improved 6MWTD and was associated with fewer serious adverse events. However, the trial lacked sufficient power to identify or refute effects on symptoms or QoL. The potential benefits of intravenous iron in HFpEF with ID should be investigated further in a larger cohort.

• Jezik: Angleški jezik
• Ključne besede: exercise capacity, heart failure, iron deficiency, preserved ejection fraction
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 3789-3800
• Številčenje: Vol. 45, iss. 37
• PID: 20.500.12556/RUL-182344
• UDK: 616.1
• ISSN pri članku: 0195-668X
• DOI: 10.1093/eurheartj/ehae479
• COBISS.SI-ID: 224962051
• Datum objave v RUL: 08.05.2026

Gradivo je del revije

• Naslov: European heart journal
• Skrajšan naslov: Eur. heart j.
• Založnik: Oxford University Press
• ISSN: 0195-668X
• COBISS.SI-ID: 25424896

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: zmogljivost pri telesni vadbi, srčno popuščanje, pomanjkanje železa, ohranjena iztisna funkcija

Projekti

• Financer: Switzerland, Glattbrugg, Vifor Pharma

• Financer: Germany, Charité, Universitätsmedizin Berlin