Environmental toxicity of selected aminoglycoside antibiotics to Lemna minor

Vake, Tilen (avtor), Krulec, Lina (avtor), Kubelj, Petra (avtor), Snoj, Tomaž (avtor)

Aminoglycoside antibiotics (AGs) are widely used in human and veterinary medicine. After administration, AGs undergo minimal metabolism and are excreted in their active form, contributing to their presence in the envi ronment. The aim of our study was to determine the ecotoxicological characteristics of five AGs commonly used in human and veterinary medicine: gentamicin, neomycin, spectinomycin, streptomycin and dihydros treptomycin. Their effects on growth and chlorophyll synthesis were investigated under laboratory conditions using the model plant organism Lemna minor. For each AG, logarithmic dilution was performed to yield test solutions with concentrations ranging from 0.001 to 100 mg/L. In the growth inhibition test, low concentrations of spectinomycin and streptomycin stimulated the growth of Lemna minor. The lowest EC₅₀ values, indicating the greatest toxicity, were detected for gentamicin and dihydrostreptomycin, at 0.397 and 0.625 mg/L, respectively. The results of the chlorophyll synthesis test revealed that neomycin and gentamicin had the lowest EC50 values, at 45.33 and 56.01 mg/L, respectively. The other AGs tested did not notably affect chlorophyll synthesis.

• Jezik: Angleški jezik
• Ključne besede: aminoglycoside antibiotics, ecotoxicity, Lemna minor, growth inhibition, chlorophyll synthesis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.05.2026
• Leto izida: 2026
• Št. strani: 18 str.
• Številčenje: Vol. 22, art. 101186
• PID: 20.500.12556/RUL-182259
• UDK: 614
• ISSN pri članku: 2772-4166
• DOI: 10.1016/j.hazadv.2026.101186
• COBISS.SI-ID: 276777987
• Datum objave v RUL: 05.05.2026

Gradivo je del revije

• Naslov: Journal of hazardous materials advances
• Založnik: Elsevier B.V.
• ISSN: 2772-4166
• COBISS.SI-ID: 103476995

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P4-0053-2019
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih