Towards greener-by-design fine chemicals : Synthetic frontiers

Gazis, Theodore A. (avtor), Wuyts, Jonas (avtor), Moutsiou, Areti (avtor), Volpin, Giulio (avtor), Ford, Mark J. (avtor), Teixeira, Rodolfo I. (avtor), Wheelhouse, Katherine M. P. (avtor), Natho, Philipp (avtor), Žnidaršič Plazl, Polona (avtor), Jost, Sonja (avtor), Luisi, Renzo (avtor), Benyahia, Brahim (avtor), Maes, Bert U. W. (avtor), Vilé, Gianvito (avtor)

In the face of intensifying market needs and mounting environmental pressures, the pharmaceutical and agrochemical sectors must revisit core aspects of process design. This review proposes a forward-looking framework for “greener-by-design” manufacturing, emphasizing the integration of sustainability from the earliest stages of synthetic planning through to industrial implementation. We focus on four interdependent levers that collectively enable this transformation: (i) solvent choice, with an emphasis on minimization, substitution, or complete elimination; (ii) substrate sourcing, favoring renewable and biomass-derived feedstocks to reduce fossil dependency; (iii) catalyst development, exploring the use of base metals, novel heterogeneous systems, and biocatalysts; and (iv) continuous-flow processing, which enhances safety, scalability, and process control. These strategies are not meant to be applied in isolation but rather in a synergistic, end-to-end manner that accounts for the full lifecycle of chemical products. By aligning synthetic efficiency with environmental responsibility, this review outlines a practical and actionable roadmap for the sustainable production of high-value fine chemicals. The convergence of synthetic chemistry with process engineering, data science, and life cycle thinking will be critical to realizing this vision, ultimately enabling more robust, circular, and future-proof manufacturing paradigms.

• Jezik: Angleški jezik
• Ključne besede: process design, catalysis, biocatalysis, sustainable production, fine chemicals
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 619-674
• Številčenje: Vol. 55, iss. 2
• PID: 20.500.12556/RUL-182244
• UDK: 66.011.097
• ISSN pri članku: 1460-4744
• DOI: 10.1039/d5cs00929d
• COBISS.SI-ID: 257931779
• Datum objave v RUL: 05.05.2026

Gradivo je del revije

• Naslov: Chemical Society reviews
• Skrajšan naslov: Chem. Soc. rev.
• Založnik: Royal Society of Chemistry
• ISSN: 1460-4744
• COBISS.SI-ID: 519832857

Licence

• Licenca: CC BY 3.0, Creative Commons Priznanje avtorstva 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by/3.0/deed.sl
• Opis: Dovoljuje kopiranje in razširjanje vsebin v kakršnemkoli mediju in obliki. Dovoljuje remixanje, urejanje, predelava in vključevanje vsebine v lastna dela v vse namene, tudi komercialne. Primerno morate navesti avtorja, povezavo do licence in označiti spremembe, če so kakšne nastale. To lahko storite na kakršenkoli razumen način, vendar ne na način, ki bi namigoval na to, da dajalec licence podpira vas ali vašo uporabo dela. Ne smete uporabiti pravnih določil ali tehničnih ukrepov, ki bi pravno omejili ali onemogočilo druge, da bi storili karkoli, kar licenca dovoli.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: načrtovanje procesov, kataliza, biokataliza, trajnostna proizvodnja, fine kemikalije