In vitro bioaccessibility of lutein diesters in relation to their chemical structure

Krstić, Đurđa (avtor), Bolko Seljak, Katarina (avtor), Grilc, Blaž (avtor), German Ilić, Ilija (avtor), Slatnar, Ana (avtor), Albreht, Alen (avtor)

This study investigated the bioaccessibility of ten synthetic lutein diesters using the in vitro INFOGEST human digestion model, enabling comparative evaluation of their digestive behavior under controlled food-matrix conditions. We revealed that lutein ester chain length was the primary determinant of bioaccessibility, while branching influenced the extent of hydrolysis. Linear short-chain diesters demonstrated superior bioaccessibility (6.7–18.9%). Branched and bulky derivatives, surprisingly, achieved comparable bioaccessibility (6.6–8.3%) despite high hydrolytic resistance, suggesting mechanisms beyond simple ester cleavage. Conversely, long-chain lutein diesters (> C10), prevalent in commercial supplements, exhibited poor micellization, limited hydrolysis, and consequently very low bioaccessibility (<3%). Finally, two pharmaceutical formulations of the lead lutein diester, lutein di(2,2-dimethylpropanoate), were developed: a sunflower oil formulation and a liquisolid formulation utilizing a porous aluminometasilicate carrier. The sunflower oil formulation enabled significantly higher pigment stability and bioaccessibility, highlighting its superior potential for effective lutein delivery in novel food and pharmaceutical applications.

• Jezik: Angleški jezik
• Ključne besede: lutein diesters, INFOGEST in vitro digestion, bioaccessibility, hydrolysis efficiency, chemical structure, structure-property relationship
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 12 str.
• Številčenje: Vol. 509, art. 148572
• PID: 20.500.12556/RUL-180564
• UDK: 542:616.3-008
• ISSN pri članku: 1873-7072
• DOI: 10.1016/j.foodchem.2026.148572
• COBISS.SI-ID: 271138307
• Datum objave v RUL: 11.03.2026

Gradivo je del revije

• Naslov: Food chemistry
• Založnik: Elsevier
• ISSN: 1873-7072
• COBISS.SI-ID: 23392261

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: luteinski diestri, INFOGEST in vitro prebava, biološka dostopnost, učinkovitost hidrolize, kemijska struktura, razmerje med strukturo in lastnostmi, prebavne motnje