The impact of histopathology on prognosis of squamous cell carcinoma of the larynx : can we do better?

Zidar, Nina (avtor), Thompson, Lester D. R. (avtor), Agaimy, Abbas (avtor), Stenman, Göran (avtor), Hellquist, Henrik (avtor), Nadal, Alfons (avtor), Mäkitie, Antti A. (avtor), López, Fernando (avtor), Strojan, Primož (avtor), Ferlito, Alfio (avtor)

Despite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using international guidelines. These include extra- vs intratumoural vascular and perineural invasion, tumour budding, depth of invasion, and tumour-infiltrating lymphocytes. We also address the problem of specimen quality and type (open approach vs endoscopic surgery) and the related limitations. High-risk human papillomavirus infection is another controversial issue to be discussed, being rare in laryngeal SCC, with an indeterminate prognostic significance and less reliable p16 overexpression as a surrogate marker of HPV infection. Further studies are warranted to address the applicability and to see which of the described parameters may help to better stratify patients with laryngeal SCC and should therefore be included in the pathology report.

• Jezik: Angleški jezik
• Ključne besede: larynx, biomarkers, disease progression, human papillomavirus, lymphocytes, tumour-infiltrating, morbidity, precision medicine, prognosis, squamous cell carcinoma
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 13–32
• Številčenje: Vol. 487, iss. 1
• PID: 20.500.12556/RUL-178430
• UDK: 616-006
• ISSN pri članku: 0945-6317
• DOI: 10.1007/s00428-025-04082-w
• COBISS.SI-ID: 232364035
• Datum objave v RUL: 27.01.2026

Gradivo je del revije

• Naslov: Virchows archiv
• Skrajšan naslov: Virchows arch.
• Založnik: Springer Nature
• ISSN: 0945-6317
• COBISS.SI-ID: 7571161

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: larinks, grlo, biološki označevalci, napredovanje bolezni, humani papiloma virus, HPV, limfociti, infiltracija tumorja, obolevnost, precizna medicina, ploščatocelični karcinom

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0054
• Naslov: Patologija in molekularna genetika