New coordination modes of furosemide anion in copper(II) complexes : synthesis and structural insights

Podjed Rihtaršič, Nina (avtor), Modec, Barbara (avtor)

The coordination chemistry of copper(II) was explored using furosemide, a sulphonamide-based diuretic, as a ligand. A series of new copper(II) compounds with furosemide was synthesised and structurally characterised by single crystal X-ray diffraction. Within this series, two novel coordination modes of the deprotonated furosemide (abbreviated as fur$^−$) were identified. The first one is a bidentate bridging mode (μ$_2$-η$^1$:η$^1$), found in dinuclear paddle-wheel (PW) complexes [Cu$_2$(fur)$_4$(CH$_3$CN)$_2$]⋅2(CH$_3$CH$_2$)$_2$O (3) and [Cu$_2$(fur)$_4$(CH$_3$CH$_2$OH)$_2$]⋅2CH$_3$CH$_2$OH⋅2H$_2$O (4), where carboxylate oxygens of the furosemide anion link two copper(II) centres. The second one is a unique bridging mode (μ$_3$-η$^1$:η$^1$:η$^1$), in which the furosemide anion coordinates not only through the carboxylate oxygens but also via the sulphonamide oxygen atom, thereby linking three copper(II) ions to form a one-dimensional coordination polymer [Cu$_2$(fur)$_4$]$_n$⋅4n(CH$_3$CH$_2$OH)⋅2n(H$_2$O) (5). Introduction of quinaldinate (quin$^−$, anion of quinoline-2-carboxylic acid) into the reaction mixture yielded the cocrystal [Cu(quin)$_2$]$_n$⋅2n(furH) (6), consisting of a quinaldinate-based one-dimensional coordination polymer and neutral furosemide molecules attached to the coordination polymer through hydrogen bonding. These findings provide the first structural evidence of furosemide exhibiting both bidentate and tridentate bridging behaviour, highlighting its remarkable flexibility as a ligand. Overall, this work reveals the structural diversity of resulting copper(II) complexes and broadens the understanding of ligand-metal interactions, offering new perspectives for the design of functional coordination compounds based on bioactive ligands.

• Jezik: Angleški jezik
• Ključne besede: furosemide, quinaldinate, copper(II), coordination chemistry, crystal structure
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 9 str.
• Številčenje: Vol. 184, art. 115916
• PID: 20.500.12556/RUL-176703
• UDK: 546.562:547.7
• ISSN pri članku: 1387-7003
• DOI: 10.1016/j.inoche.2025.115916
• COBISS.SI-ID: 260552451
• Datum objave v RUL: 09.12.2025

Gradivo je del revije

• Naslov: Inorganic chemistry communications
• Skrajšan naslov: Inorg. chem. commun.
• Založnik: Elsevier
• ISSN: 1387-7003
• COBISS.SI-ID: 759599

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: furosemid, kinaldinat, baker(II), koordinacijska kemija, kristalna struktura

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P1-0134-2022
• Naslov: Kemija za trajnostni razvoj

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: I0-0022-2022
• Naslov: Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)