Contact urticaria and related conditions : clinical review

Bizjak, Mojca (avtor), Košnik, Mitja (avtor)

Contact urticaria (CoU) is an immediate contact reaction occurring within minutes to an hour after exposure to specific proteins or chemicals. CoU is categorised into non-immunologic (NI-CoU) and immunologic (I-CoU) types, with I-CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the CoU syndrome. Patients with I-CoU may also have other type I (immediate) allergic diseases, such as allergic conjunctivitis, rhinitis, asthma or food allergy. This review provides a detailed overview of CoU and related conditions, focusing on triggers, diagnostic methods and management strategies. NI-CoU is typically triggered by low molecular weight chemicals, while I-CoU involves IgE-mediated hypersensitivity to both high molecular weight proteins and low molecular weight chemicals. Early diagnosis is crucial, though CoU is often underrecognized. The diagnostic approach includes a thorough medical history, physical examination, evaluation of photographs, (non)invasive skin tests and in vitro assessments. Management strategies prioritise trigger avoidance and pharmacological treatments when avoidance is not fully possible. For I-CoU, second-generation H1-antihistamines are the first-line treatment. Severe cases of I-CoU may benefit from anti-IgE therapy (omalizumab). Patients at risk of anaphylaxis should carry an adrenaline auto-injector and wear a medical alert bracelet.

• Jezik: Angleški jezik
• Ključne besede: inducible urticaria, occupational urticaria, protein contact dermatitis, urticaria, anaphylaxis, histamine antagonists, epinephrine, contact dermatitis, contact urticaria
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 87-107
• Številčenje: Vol. 93, iss. 2
• PID: 20.500.12556/RUL-176687
• UDK: 616.5-002:616.97
• ISSN pri članku: 1600-0536
• DOI: 10.1111/cod.14794
• COBISS.SI-ID: 232153859
• Datum objave v RUL: 09.12.2025

Gradivo je del revije

• Naslov: Contact dermatitis
• Založnik: Wiley
• ISSN: 1600-0536
• COBISS.SI-ID: 517686809

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: izzvana urtikarija, poklicna urtikarija, dermatitis ob stiku z beljakovinami, anafilaksija, kontaktni dermatitis, urtikarija, antagonisti histamina, adrenalin

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0360
• Naslov: Celostna obravnava alergijskih bolezni in astme v Sloveniji: od epidemiologije do genetike