PLA2G4E in health and disease : insights from omics and functional analyses

Čater, Maša (avtor), Šimon, Martin (avtor), Morton, Nicholas M. (avtor), Kunej, Tanja (avtor), Horvat, Simon (avtor)

The phospholipase A2 (PLA2) enzyme superfamily has been extensively studied, but omprehensive reviews on cytosolic phospholipase A2 group IVE (PLA2G4E) remain scarce, limiting our understanding of its role in lipid metabolism and disease. Our review synthesizes current findings on the human PLA2G4E gene and its murine ortholog Pla2g4e, drawing from multi-omics analyses and a range of functional studies. Pla2g4e exhibits distinct expression patterns across tissues, suggesting potential tissue-specific roles. In addition to its phospholipase activity, PLA2G4E exhibits N-acyltransferase activity and responds to calcium influx. Emerging evidence suggests possible involvement in metabolic disorders such as obesity and diabetes, particularly through effects on glucose uptake and insulin sensitivity. PLA2G4E has been implicated in the synthesis of N-acylethanolamines with potential effects on energy homeostasis, stress adaptation, neuronal signaling, pain perception, cognition, and motor coordination. Genomic and preliminary functional evidence further point to possible roles in immune regulation and neurobiology, with some associations reported in neurodegenerative diseases such as Alzheimer’s disease. Comprehensive insights into the biological roles of PLA2G4E are essential for clarifying its enzymatic functions and potential involvement in disease mechanisms; however, further experimental and clinical studies are needed to substantiate these emerging associations and assess its therapeutic potential.

• Jezik: Angleški jezik
• Ključne besede: phospholipases, lipid metabolism, muscles, adipose tissue, fatty acid metabolism, obesity, diabetes, N-acylethanolamine
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.11.2025
• Leto izida: 2025
• Št. strani: 20 str.
• Številčenje: Vol. 100, [article no.] ǂ101359
• PID: 20.500.12556/RUL-175995
• UDK: 575
• ISSN pri članku: 1873-2194
• DOI: 10.1016/j.plipres.2025.101359
• COBISS.SI-ID: 257136131
• Datum objave v RUL: 17.11.2025

Gradivo je del revije

• Naslov: Progress in lipid research
• Založnik: Elsevier
• ISSN: 1873-2194
• COBISS.SI-ID: 23276293

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: genetika, geni, PLA2G4E, debelost, diabetes, biokemija

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: J4-2548
• Naslov: Vpliv RNA variant na fenotipsko raznolikost pri živalskih modelih

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P4-0220
• Naslov: Primerjalna genomika in genomska biodiverziteta