Relationship between dietary pesticide intake and urinary excretion : a pilot study using duplicate portion analysis

Wieland, Nina C. (avtor), Martins Figueiredo, Daniel (avtor), Mol, Hans (avtor), Glavan, Matjaž (avtor), Blagus, Tanja (avtor), Dolžan, Vita (avtor), Scheepers, Paul T. J. (avtor)

Dietary uptake is estimated using residue data from food commodities and predicting the effect of food processing, such as peeling. The aim of this study was to explore the value of the analysis of duplicate portions supplemented by the analysis of urinary metabolites. Forty-three participants, consuming organic and non-organic diets collected a duplicate portion of food and beverages for 24 h. Urine was collected up to 36 h to account for metabolism and prolonged excretion of metabolites. Pesticide residues were analysed in food portions and urine samples using LC-MS/MS and GC-MS/MS. Multiple pesticide residues were detected per food portion. Out of 183 pesticides, 86 were detected in the diet. Glyphosate and AMPA were detected in 42 % and 30 % of all urine samples, respectively, while detection in the diet was low. A positive relationship between dietary intake and urinary excretion was found for 2,4-D and MCPA. No diet-urine relationship was observed for glyphosate and AMPA, indicating contribution from external routes of exposure. Hazard index (HI) indicated no exposure above the acceptable daily intake (ADI) for all participants. This study demonstrates how DPA combined with urine analysis gives insight into contribution of diet to total pesticide exposure compared to standard monitoring.

• Jezik: Angleški jezik
• Ključne besede: plant protection products, biocides, biological monitoring, dietary exposure
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 11 str.
• Številčenje: art. 105972, Vol. 164
• PID: 20.500.12556/RUL-175598
• UDK: 61
• ISSN pri članku: 0273-2300
• DOI: 10.1016/j.yrtph.2025.105972
• COBISS.SI-ID: 255947523
• Datum objave v RUL: 05.11.2025

Gradivo je del revije

• Naslov: Regulatory toxicology and pharmacology
• Skrajšan naslov: Regul. toxicol. pharmacol.
• Založnik: Academic Press
• ISSN: 0273-2300
• COBISS.SI-ID: 26265600

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: fitofarmacevtska sredstva, biocidi, sredstva za varstvo rastlin, prehranska izpostavljenost, biološki monitoring

Projekti

• Financer: EC - European Commission
• Program financ.: H2020
• Številka projekta: 862568
• Naslov: Sustainable plant protection transition: a global health approach
• Akronim: SPRINT

• Financer: FCT - Fundação para a Ciência e a Tecnologia, I.P.
• Številka projekta: UIDP/50017/2020
• Naslov: Centre for Environmental and Marine Studies
• Akronim: CESAM