Epigenetic rejuvenation through partial cell reprogramming enables the restoration of a youthful epigenetic profile while preserving cellular identity. It is based on the reversible remodelling of epigenetic marks, with DNA methylation, post-translational histone modifications, and chromatin reorganisation playing a crucial role. The gradual loss of epigenetic stability is a characteristic feature of ageing and leads to a decline in cellular functionality and a reduction in the regenerative potential of tissues. Partial reprogramming allows partial restoration of the original epigenetic landscape, reducing phenotypic signs of ageing and improving cellular functionality without complete dedifferentiation. Due to these properties, this approach opens up possibilities for the
development of therapeutic strategies aimed at slowing down ageing and extending the healthspan. However, important questions remain regarding long-term effects, ethical considerations, safety, and clinical applicability.
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