Synthesis of a fac-tricarbonylrhenium(I) complex with pyrithione, its physicochemical characterization, and assessment of biological effects

Rapuš, Uroš (avtor), Pivarcsik, Tamás (avtor), Mitrović, Ana (avtor), Kljun, Jakob (avtor), Bogdanov, Anita (avtor), Spengler, Gabriella (avtor), Meden, Anže (avtor), Gobec, Stanislav (avtor), Kos, Janko (avtor), Enyedy, Éva Anna (avtor), Turel, Iztok (avtor)

Research on rhenium complexes containing fac-tricarbonyl fragments has been on the rise in recent decades. Some complexes of this type exhibit advantageous properties that can be utilized in diagnostic and therapeutic applications. Herein, we report on the synthesis, structural characterization, solution speciation, and biological activity with mode of action studies of a new fac-tricarbonylrhenium(I) complex with pyrithione ligand fac-[Re(CO)$_3$(pyrithionato)(benzonitrile)] (4). In an attempt to prepare a stable rhenium(I) complex with a pyrithionato ligand, several synthesis procedures were investigated and various products were discovered. In solution, the monodentate benzonitrile ligand can be replaced by a coordinating solvent molecule; however, the carbonyl ligands and pyrithione remain bound to the rhenium center. Complex 4 exhibited strong cytotoxic and antibacterial activity and effectively inhibited the growth of the HSV-2 virus. Additionally, complex 4 was also able to inhibit the cathepsin B enzyme (both its endo- and exopeptidase activities). In silico experiments confirmed that complex 4 can interact with cathepsin B near its active site, which may contribute to reduced enzymatic activity.

• Jezik: Angleški jezik
• Ključne besede: antimicrobial agents, degradation, inhibition, ligands, peptides, proteins
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo ; FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 38272-38291
• Številčenje: Vol. 10, iss. 33
• PID: 20.500.12556/RUL-172601
• UDK: 546.719:547.82
• ISSN pri članku: 2470-1343
• DOI: 10.1021/acsomega.5c06647
• COBISS.SI-ID: 247217923
• Datum objave v RUL: 09.09.2025

Gradivo je del revije

• Naslov: ACS omega
• Skrajšan naslov: ACS omega
• Založnik: American Chemical Society
• ISSN: 2470-1343
• COBISS.SI-ID: 525873945

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: renij, trikarbonilrenijevi(I) kompleksi, pirition, biološka aktivnost