In the diploma thesis, the detection of drying stages in the lyophilization process in a vial at the laboratory testing level was studied. Using a heat flux meter, it was possible to monitor the transitions between individual drying phases in real time and accurately determine their end. The results showed that appropriate detection of the end of each drying phase enables a reduction of the total drying cycle by approximately 10 hours and consequently an energy saving of up to 34 % over the entire cycle, without any negative impact on the quality of the final product. In addition, the research confirms that laboratory testing is important for the development and optimization of process parameters, which can later be transferred to the industrial level.
|
