The pursuit of process intensification led to an introduction of innovations in chemical engineering and related fields at the end of the 20th century, such as a growing preference for continuous processing strategies and miniaturization which enabled the development of microfluidics. This technology includes a range of tools for manipulation of fluids in channels measuring from 10$^{-6}$ to 10$^{-4}$ meters. Its application offers numerous advantages: microstructured devices occupy less physical space, leading to reduced raw material consumption and enhanced process safety, however key advantage of microfluidics is improved control over various transport phenomena (mass, momentum, and energy transfer). Furthermore, the continuous operation of (micro)reactors is gaining attraction due to the numerous benefits it provides, including enhanced efficiency and capability of integrating various process phases. Continuous flow microstructured systems are relevant in several phases of (bio)chemical processes, particularly in downstream processes (DSPs), where the primary objective is recovery of the main product. This can be achieved by employing various separation processes, including precipitation, filtration, chromatography, distillation, and pervaporation. Pervaporation is a membrane-based separation technique, allowing the separation of multi-component mixture. In context of a binary mixture, the pressure difference between the liquid phase and the gas phase on the opposite side of the membrane serves as the driving force for mass transfer of one of the components through the membrane while the other component remains in the liquid phase. Unlike distillation, pervaporation operates under milder conditions, resulting in lower energy consumption, and it is not limited by the thermodynamic equilibrium between the liquid and vapor phases, facilitating the separation of azeotropic mixtures. The master’s thesis was focused on the development and application of continuous pervaporation-based separation process in a microstructured device. By employing a laboratory-scale microstructured device, I investigated how various operating conditions (retention time, pressure, and initial concentration) affect the separation of selected model molecules. Specifically, the thesis analysed the separation of acetone from water, as well as the separation of acetophenone – a common industrial by-product – from an aqueous phosphate buffer solution. Additionally, the effect of the addition of a deep eutectic solvent (DES) on the separation process was examined.
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