Enaminones are important compounds for the synthesis of complex organic molecules, as their structure allows them to partake in numerous reactions. Two of these are aza-de Mayo reaction and photocatalyzed hydrogen atom transfer (HAT), which can be used to quickly obtain cyclic compounds via annulation. In my diploma thesis, I synthesized a ketone from Weinreb's amide of a substituted glycolic acid, and converted it into an enaminone using N,N-dimethylformamide dimethyl acetal (DMFDMA). I used the enaminone and several other derivatives in the aza-de Mayo reaction and in photocatalyzed HAT reaction. I also carried out the 1,4-addition of a Grignard reagent on enaminone reagents.
|
