Griseofulvin is a natural metabolite of some species of fungi, which has been used in pharmacy for a long time as a systemic antifungal drug. Recently, the usefulness of griseofulvin and its derivatives has been tested in various fields, such as anticancer activity, treatment of neurodegenerative diseases, antibacterial and immunomodulatory activity. The purpose of my work was to synthesize and characterize various derivatives of griseofulvin, which could be used for further testing. As part of my diploma thesis, I synthesized and isolated 8 derivatives of griseofulvin and recorded their $^1$H-NMR-, $^{13}$C-NMR-, HRMS- and IR-spectrum and determined the melting interval.
Griseofulvin is a relatively complex and diverse molecule, which consequently has diverse chemistry. Based on the conversions from literature, I tried to determine the mechanisms of various conversions that can be achieved on griseofulvin and tried to connect them with the known principles of conversions from organic chemistry.
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