Modeling how lamellipodia-driven cells maintain persistent migration and interact with external barriers

Sadhukhan, Shubhadeep (avtor), Martinez-Torres, Cristina (avtor), Penič, Samo (avtor), Beta, Carsten (avtor), Iglič, Aleš (avtor), Gov, Nir S. (avtor)

Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the intracellular transport of polarity cues due to the global actin retrograde flow. This mechanism was termed the “Universal Coupling between cell Speed and Persistency”(UCSP). Here we implement a simplified version of the UCSP mechanism in a coarse-grained “minimal-cell” model, which is composed of a three-dimensional vesicle that contains curved active proteins. This model spontaneously forms a lamellipodia-like motile cell shape, which is, however, sensitive and can depolarize into a nonmotile form due to random fluctuations or when interacting with external obstacles. The UCSP implementation introduces long-range inhibition, which stabilizes the motile phenotype. This allows our model to describe the robust polarity observed in cells and explain a large variety of cellular dynamics, such as the relation between cell speed and aspect ratio, cell-barrier scattering, and cellular oscillations in different types of geometric confinements.

• Jezik: Angleški jezik
• Ključne besede: external barriers, cell movement, dynamics, cell polarity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 013319-1-013319-13
• Številčenje: Vol. 7, issue 1, art. 013319
• PID: 20.500.12556/RUL-171060
• UDK: 577
• ISSN pri članku: 2643-1564
• DOI: 10.1103/PhysRevResearch.7.013319
• COBISS.SI-ID: 230871555
• Datum objave v RUL: 30.07.2025

Gradivo je del revije

• Naslov: Physical review research
• Založnik: American Phyisical Society
• ISSN: 2643-1564
• COBISS.SI-ID: 32822823

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: zunanje ovire, gibanje celice, dinamika, polarnost celice