Spelt grass juice : phytochemicals and antiproliferative activity

Topalović, Ana (avtor), Knežević, Mirko (avtor), Mikulič Petkovšek, Maja (avtor), Mrđanović, Jasminka Ž. (avtor)

Spelt is gaining popularity due to its nutritional and ecological benefits, particularly in organic farming. Juice from young spelt grass is rich in potassium, phosphorus, manganese, and chromium, along with beneficial pigments and phenolic compounds, all of which support human health. This study examines the phytochemical composition (photopigments and phenolics) determined by visible spectrophotometry and liquid chromatography, as well as the antiproliferative effects of spelt grass juice extracts assessed by the MTT assay. It also explores their selectivity towards human malignant cells (lung A-549 and cervical HeLa) and their potential synergy with doxorubicin, an anticancer drug. Spelt grass juice extracts, particularly aqueous and methanol–water extracts, contained significant amounts of ferulic acid and its derivatives. The methanol–water extracts were similar to aqueous extracts in terms of total phenolics (3464–3601 µg/g DW), while the acetone–water extracts had a significantly lower content (around 2700 µg/g DW). The antiproliferative effect of spelt extracts was moderate, with the acetone–water extract showing the highest selectivity towards HeLa cells, likely due to its ability to extract both photopigments and phenolics. Co-treatment with doxorubicin enhanced the cytotoxic effects. These findings highlight the potential of Triticum spelta extracts to improve the efficacy of conventional chemotherapeutic agents.

• Jezik: Angleški jezik
• Ključne besede: spelt grass, spelt grass juice, spelt water, extract, potassium, phosphorus, manganese, chromium, phenolic compounds, phytochemical composition, organic farming, human malignant cells, doxorubicin, anticancer drugs, cytotoxic effects
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 16 str.
• Številčenje: Vol. 16, iss. 9, art. 4917
• PID: 20.500.12556/RUL-169915
• UDK: 633.111
• ISSN pri članku: 2076-3417
• DOI: doi.org/10.3390/app15094917
• COBISS.SI-ID: 239297539
• Datum objave v RUL: 16.06.2025

Gradivo je del revije

• Naslov: Applied sciences
• Skrajšan naslov: Appl. sci.
• Založnik: MDPI
• ISSN: 2076-3417
• COBISS.SI-ID: 522979353

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: pira, sok pire, izvleček pire, ekstrakcija, kalij, fosfor, mangan, krom, fenolne snovi, fitokemijska sestava, organsko kmetijstvo, človeške maligne celice, zdravila, rak (medicina), citotoksični učinki, Proteus anguinus parkelj