Curry plant (Helichrysum italicum) is an aromatic plant known for its bright yellow flowers. Due to its beneficial effects, it has been widely used in traditional medicine, and in recent decades, it has become a popular ingredient in the cosmetics industry. It is most commonly used in the form of creams, serums and ointments, which have anti-inflammatory, antioxidant and antimicrobial properties. With the increasing use of curry plant as a cosmetic ingredient, comprehensive safety assessment is crucial to ensure consumer's protection from potential health risks. In our thesis, we used the Threshold of Toxicological Concern (TTC) approach, which classifies chemical compounds into appropriate Cramer toxicity classes with defined exposure limits, based on their chemical structures. As part of the research, we reviewed the quantitative and qualitative composition of curry plant and its extract using available literature. Based on the physicochemical properties, we assessed the potential extent of absorption and systemic exposure for each compound. For substances with unknown concentrations in the extract, we calculated the maximal tolerated systemic exposure based on potential extent of absorption and the TTC value of the Cramer classification scheme. For certain compounds, we also calculated the acceptable daily intake by employing the NOAEL values. The values of acceptable daily intake were significantly higher than the values determined using the TTC approach and the estimated systemic exposure. Based on the obtained data, we were able to conclude that curry plant extract is safe for use in cosmetic products.
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