Design optimisation of a flat-panel, limited-angle TOF-PET scanner : a simulation study

Orehar, Matic (avtor), Dolenec, Rok (avtor), El Fakhri, Georges (avtor), Korpar, Samo (avtor), Križan, Peter (avtor), Razdevšek, Gašper (avtor), Marin, Thibault (avtor), Žontar, Dejan (avtor), Pestotnik, Rok (avtor)

In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner. However, achieving adequate CTR is a considerable challenge and requires improvements at every level of detection. Based on recent results in the ongoing development of optimised TOF-PET photodetectors and electronics, we expect that within a few years, a CTR of about 75 ps will be achievable at the system level. In this work, flat-panel scanners with four panels and various design parameters were simulated, assessed and compared to a reference scanner based on the Siemens Biograph Vision using NEMA NU 2-2018 metrics. Point sources were also simulated, and a method for evaluating spatial resolution that is more appropriate for flat-panel geometry is presented. We also studied the effects of crystal readout strategies, comparing single-crystal and module readout levels. The results demonstrate that with a CTR below 100 ps, a flat-panel scanner can achieve image quality comparable to that of a reference clinical scanner, with considerable savings in scintillator material.

• Jezik: Angleški jezik
• Ključne besede: PET detector development, time-of-flight, time-of-flight positron emission tomography, TOF-PET, GATE, Monte Carlo simulation, CASToR
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FMF - Fakulteta za matematiko in fiziko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 15 str.
• Številčenje: Vol. 14, iss. 17, art. 1976
• PID: 20.500.12556/RUL-169395
• UDK: 539.1
• ISSN pri članku: 2075-4418
• DOI: 10.3390/diagnostics14171976
• COBISS.SI-ID: 207781123
• Datum objave v RUL: 27.05.2025

Gradivo je del revije

• Naslov: Diagnostics
• Skrajšan naslov: Diagnostics
• Založnik: MDPI
• ISSN: 2075-4418
• COBISS.SI-ID: 519963673

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: pozitronska emisijska tomografija, razvoj tomografov, čas preleta, tomografija, metoda Monte Carlo