A cross-sectional study of laboratory parameters 5–6 months after the first COVID-19 infection

Zore, Taja (avtor), Lojk, Jasna (avtor), Reberšek, Katarina (avtor), Božnar Alič, Elizabeta (avtor), Čegovnik Primožič, Urška (avtor), France Štiglic, Alenka (avtor), Jerin, Aleš (avtor), Prodan Žitnik, Irena (avtor), Podgornik, Helena (avtor), Snoj, Nada (avtor), Ostanek, Barbara (avtor), Turel, Gabriele (avtor), Lejko-Zupanc, Tatjana (avtor), Marc, Janja (avtor), Černe, Darko (avtor)

Objectives: Despite extensive study of COVID-19 disease, only a few studies also addressed the aftermath of the disease and potential long-term consequences. The aim of this study was to assess COVID-19 resolution through the cross-sectional analysis of an extensive range of haematological and biochemical laboratory parameters and to find potential markers still associated with disease severity 5-6-months post infection. Methods: In this study, we analysed 92 routine biochemical, haematological and immunological parameters in 75 non-vaccinated patients 5–6 months after recorded first time SARS-CoV-2 infection without reinfection. Demographic and disease severity data were obtained through surveys. Results: The majority of analysed parameters were within the normal reference intervals, however, statistically significant correlations with the disease severity were detected in 15 parameters: B lymphocytes, NK cells, interleukin (IL)-12, IL-1β, cortisol, ferritin, SARS-CoV-2 specific IgG and IgM antibodies, Na, Cl, creatinine, alkaline phosphatase, cholesterol, HbA1c and alpha 2 and beta 2 globulin fractions of the proteinogram. Conclusions: Although most observed parameters returned to their normal reference intervals, significant correlations were still observed with disease severity, that could indicate either the pre-infection baseline state which affected disease outcome or minor remaining alterations in function of certain organs, pertaining their stress or damage during the acute phase of the disease.

• Jezik: Angleški jezik
• Ključne besede: disease severity, laboratory parameters, resolution, COVID-19, SARS-CoV-2
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 12 str.
• Številčenje: Vol. 11, iss. 4, art. e42535
• PID: 20.500.12556/RUL-168506
• UDK: 542:616.98:578.834
• ISSN pri članku: 2405-8440
• DOI: 10.1016/j.heliyon.2025.e42535
• COBISS.SI-ID: 232905475
• Datum objave v RUL: 16.04.2025

Gradivo je del revije

• Naslov: Heliyon
• Založnik: Elsevier
• ISSN: 2405-8440
• COBISS.SI-ID: 21607432

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: resnost bolezni, laboratorijski parametri, resolucija, COVID-19, SARS-CoV-2, laboratorijska kemija, laboratorijska medicina