Biophysics and electrophysiology of pulsed field ablation in normal and infarcted porcine cardiac ventricular tissue

Miklavčič, Damijan (avtor), Verma, Atul (avtor), Krahn, Philippa R. P. (avtor), Štublar, Jernej (avtor), Kos, Bor (avtor), Escartin, Terenz (avtor), Lombergar, Peter (avtor), Coulombe, Nicolas (avtor), Terricabras Casas, Maria (avtor), Jarm, Tomaž (avtor), Kranjc, Matej (avtor)

Pulsed Field Ablation (PFA) is a new ablation method being rapidly adopted for treatment of atrial fibrillation, which shows advantages in safety and efficiency over radiofrequency and cryo-ablation. In this study, we used an in vivo swine model (10 healthy and 5 with chronic myocardial infarct) for ventricular PFA, collecting intracardiac electrograms, electro-anatomical maps, native T1-weighted and late gadolinium enhancement MRI, gross pathology, and histology. We used 1000–1500V pulses, with 1–16 pulse trains to vary PFA dose. Lesions were assessed at 24 h, 7 days, and 6 weeks in healthy and at 48 h in infarcted ventricles. Comparisons of lesion sizes using a numerical model enabled us to determine lethal electric field thresholds for cardiac tissue and its dependence on the number of pulse trains. Similar thresholds were found in normal and infarcted hearts. Numerical modeling and temperature-sensitive MRI confirmed the nonthermal nature of PFA, with less than 2% of a lesion’s volume at the highest dose used being attributed to thermal damage. Longitudinal cardiac MRI and histology provide a comprehensive description of lesion maturation. Lesions shrink between 24 h and 7 days post-ablation and then remain stable out to 6 weeks post-ablation. Periprocedural electrograms analysis yields good correlation with lesion durability and size

• Jezik: Angleški jezik
• Ključne besede: ventricular arrhythmias, electroporation, pulsed filed ablation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 22 str.
• Številčenje: 14, art. 32063
• PID: 20.500.12556/RUL-166863
• UDK: 004.93:616.13-007.64:537.635
• ISSN pri članku: 2045-2322
• DOI: 10.1038/s41598-024-83683-y
• COBISS.SI-ID: 221586947
• Datum objave v RUL: 28.01.2025

Gradivo je del revije

• Naslov: Scientific reports
• Skrajšan naslov: Sci. rep.
• Založnik: Nature Publishing Group
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: srčne aritmije, elektroporacija, katetrska ablacija