COVID-19 and cholesterol biosynthesis : towards innovative decision support systems

Kočar, Eva (avtor), Pušnik, Žiga (avtor), Skubic, Cene (avtor), Režen, Tadeja (avtor), Mraz, Miha (avtor), Moškon, Miha (avtor), Rozman, Damjana (avtor)

With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol biosynthesis by comparing 10 intermediates of cholesterol biosynthesis during the hospitalization of 164 patients (admission, disease deterioration, discharge) admitted to the University Medical Center of Ljubljana. The concentrations of zymosterol, 24-dehydrolathosterol, desmosterol, and zymostenol were significantly altered in COVID-19 patients. We further developed a predictive model for disease severity based on clinical parameters alone and their combination with a subset of sterols. Our machine learning models applying 8 clinical parameters predicted disease severity with excellent accuracy (AUC = 0.96), showing substantial improvement over current clinical risk scores. After including sterols, model performance remained better than COVID-GRAM. This is the first study to examine cholesterol biosynthesis during COVID-19 and shows that a subset of cholesterol-related sterols is associated with the severity of COVID-19.

• Jezik: Angleški jezik
• Ključne besede: assessment in health technology, lipid, bioinformatics
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; FRI - Fakulteta za računalništvo in informatiko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 17 str.
• Številčenje: Vol. 26, iss. 10, art. 107799
• PID: 20.500.12556/RUL-165284
• UDK: 61:60:578
• ISSN pri članku: 2589-0042
• DOI: 10.1016/j.isci.2023.107799
• COBISS.SI-ID: 165467907
• Datum objave v RUL: 29.11.2024

Gradivo je del revije

• Naslov: iScience
• Založnik: Elsevier
• ISSN: 2589-0042
• COBISS.SI-ID: 24098568

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: COVID-19, holesterol, biosinteza, steroli, lipidi, bioinformatika, ocenjevanje v zdravstveni tehnologiji