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Nano spray-dried particles of in-situ crosslinked alginate and their toxicological characterisation
ID Levanič, Jaka (Avtor), ID Osojnik Črnivec, Ilja Gasan (Avtor), ID Rozman, Iza (Avtor), ID Skrt, Mihaela (Avtor), ID Štern, Alja (Avtor), ID Žegura, Bojana (Avtor), ID Poklar Ulrih, Nataša (Avtor)

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Izvleček
The feasibility and technical capacity for producing crosslinked sub-micron gels with a nano spray-dryer were studied with variable pH systems incorporating alginate, pectin, and pullulan. The obtained powders were characterized for their morphology, particle size distribution, and their toxicological safety profile using genotoxicity and cytotoxicity assays. Additionally, quercetin was added to the encapsulation system to study the potential of the system to encapsulate this material. The produced powders exhibited morphologies and particle size distributions characteristic for nano spray-drying. The addition of pullulan and pectin to the feed solutions resulted in a particle size increase, with crosslinked alginate particles having a mean value of 1.43 μm, while particles with added pectin and pullulan had a mean particle size of 1.70 and 1.75 μm, respectively. The inclusion of quercetin proved to be problematic with this encapsulation system. Extremely high degradation rates and extremely low encapsulation efficiencies were observed due to the alkaline pH (~10) of the system that is needed to keep the feed dispersion in a liquid state and prevent premature crosslinking of the alginate. Although pectin and pullulan provided some protection for quercetin in the alkaline dispersion, the absolute quercetin content in the final product remained very low, with a maximum achieved encapsulation efficiency of 2.06 %. The safety profile of most produced powders was favourable, as they did not exhibit any significant cytotoxic and genotoxic activity in the HepG2 cell line, except in the case of Alginate/Pullulan which showed a 43 % decrease in cell viability at 500 μg/mL. Samples where quercetin was added did not show any increased toxicological effect.

Jezik:Angleški jezik
Ključne besede:alginate, polysaccharides, crosslinking, nano spray drying, toxicological evaluation
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:11 str.
Številčenje:Vol. 283, pt. 2, art. 137750
PID:20.500.12556/RUL-164997 Povezava se odpre v novem oknu
UDK:630*8
ISSN pri članku:1879-0003
DOI:10.1016/j.ijbiomac.2024.137750 Povezava se odpre v novem oknu
COBISS.SI-ID:215666435 Povezava se odpre v novem oknu
Datum objave v RUL:20.11.2024
Število ogledov:150
Število prenosov:72
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:International journal of biological macromolecules
Skrajšan naslov:Int. j. biol. macromol.
Založnik:Elsevier
ISSN:1879-0003
COBISS.SI-ID:107163139 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:alginat, polisaharidi, zamreženje, nanosušenje, toksikološka ocena

Projekti

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P4-0121
Naslov:Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0245
Naslov:Ekotoksiologija, toksikološka genomika in karcinogeneza

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J4-2545
Naslov:Samosestavljivi in napredni biopolimerni ovoji za mikrokapsulacijo probiotikov in starterskih kultur

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J1-4395
Naslov:Razvoj novih večfunkcionalnih nanocimov na osnovi kovinskih oksidov in njihova toksikološka karakterizacija (NaNoZymSafe)

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