N-acetylcysteine ineffective in alleviating hangover from binge drinking : a clinical study

Podobnik, Boris (avtor), Demšar, Lenart (avtor), Šarc, Lucija (avtor), Jerin, Aleš (avtor), Osredkar, Joško (avtor), Trontelj, Jurij (avtor), Roškar, Robert (avtor), Brvar, Miran (avtor)

Alcohol hangover (veisalgia) is a fairly common phenomenon. The pathogenesis of veisalgia is not understood and treatment has not yet been established. Occasionally, students take N-acetylcysteine (NAC) before binge drinking to alleviate hangover. The aim of this study was to evaluate the effect of NAC on serum levels of electrolytes, enzymes, oxidative stress biomarkers and symptoms of veisalgia in binge drinking. In this randomized, double-blind, placebo-controlled study, healthy students were randomly assigned into two groups: one receiving NAC and the other receiving a placebo. Blood samples were taken before drinking, 30 min after a 1.5 h long drinking session, and the subsequent morning. Serum levels of electrolytes, urea, enzymes, ethanol, 8-Hydroxydeoxyguanosine (8-OHdG) and N-epsilon-hexanoyl-lysine were measured. The participants completed the Acute Hangover Severity Scale (AHSS) assessment based on symptoms, and 40 students (20 male), aged 23 ± 2 years, were included in the study. Their mean blood ethanol concentration was 1.4 g/kg. Serum sodium levels were increased after drinking, and urea decreased the following morning compared to their levels before drinking in both groups. Serum 8-OHdG levels were increased after drinking and remained elevated until the following morning, compared to the levels before drinking, in both groups. NAC had no effect on sodium, urea and 8-OHdG levels or the symptoms of veisalgia. In conclusion, binge drinking causes a transient increase in serum sodium and as a prolonged increase in oxidative marker 8-OHdG levels. NAC had no effect on the sodium and 8-OHdG levels.

• Jezik: Angleški jezik
• Ključne besede: alcohol, hangover, veisalgia, NAC, sodium, dehydration, oxidative markers
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 9 str.
• Številčenje: Vol. 12, iss. 8, art. 585
• PID: 20.500.12556/RUL-162174
• UDK: 613.81+616.151.1-08
• ISSN pri članku: 2305-6304
• DOI: 10.3390/toxics12080585
• COBISS.SI-ID: 206065923
• Datum objave v RUL: 19.09.2024

Gradivo je del revije

• Naslov: Toxics : Elektronski vir
• Skrajšan naslov: Toxics
• Založnik: MDPI
• ISSN: 2305-6304
• COBISS.SI-ID: 520262681

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: alkohol, veisalgija, NAC, natrij, oksidativni markerji, alkoholni maček, dehidracija

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0019
• Naslov: Aplikativna in bazična fiziologija in patofiziologija v medicini

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Ljubljana
• Številka projekta: 20200175